Reduced Birth Weight, Decreased Early-Phase Insulin Secretion, and Increased Glucose Concentrations after Oral Glucose Tolerance Test in Japanese Women Aged 20 Years with Family History of Type 2 Diabetes
المؤلفون المشاركون
Takeuchi, Mika
Kurata, Miki
Fukuo, Keisuke
Tsuboi, Ayaka
Kitaoka, Kaori
Honda, Mari
Minato-Inokawa, Satomi
Yano, Megumu
Kazumi, Tsutomu
Wu, Bin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
We tested the hypothesis that family history of type 2 diabetes (FHD) is associated with reduced birth weight and reduced insulin secretion later in life.
Materials and Methods.
Birth weight, body composition by whole-body dual-energy X-ray absorptiometry, and homeostasis model assessment-insulin resistance were compared between Japanese women aged 20 years with positive (n=73) and negative (n=258) FHD.
A subsample of 153 women (57 with positive FHD) underwent a 75 g oral glucose tolerance test.
Multivariate logistic regression analyses were used to identify the most important determinants of FHD.
Results.
Women with positive as compared with negative FHD had lower birth weight (3132±364 vs.
3238±418 g, p=0.04).
However, the current fat mass index and trunk/leg fat ratio, sophisticated measures of general and abdominal fat accumulation, respectively, did not differ.
Women with positive FHD had a lower insulinogenic index (2.4±7.3 vs.
6.2±16, p=0.007) and higher area under the glucose curve (217±47 vs.
198±36 mg/dL/2 h, p=0.006).
However, fasting and postload insulinemia, homeostasis model assessment-insulin resistance, and Matsuda index did not differ.
In multivariate logistic regression analysis, birth weight was marginally associated with FHD (odds ratio, 0.999; 95% confidential interval, 0.98-1.00000; p=0.0509).
Conclusions.
FHD was associated not only with reduced birth weight but also with decreased early-phase insulin secretion and increased postload glucose concentrations in Japanese women aged 20 years.
These findings may be in keeping with the fetal insulin hypothesis and provide some evidence that FHD can alter size at birth, probably through genetic and shared environmental components, which consequently resulted in decreased early-phase insulin secretion and increased glucose excursion in the early twenties.
FHD was not related to sophisticated measures of general and abdominal adiposity and insulin resistance/sensitivity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honda, Mari& Tsuboi, Ayaka& Minato-Inokawa, Satomi& Kitaoka, Kaori& Takeuchi, Mika& Yano, Megumu…[et al.]. 2020. Reduced Birth Weight, Decreased Early-Phase Insulin Secretion, and Increased Glucose Concentrations after Oral Glucose Tolerance Test in Japanese Women Aged 20 Years with Family History of Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honda, Mari…[et al.]. Reduced Birth Weight, Decreased Early-Phase Insulin Secretion, and Increased Glucose Concentrations after Oral Glucose Tolerance Test in Japanese Women Aged 20 Years with Family History of Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1183478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honda, Mari& Tsuboi, Ayaka& Minato-Inokawa, Satomi& Kitaoka, Kaori& Takeuchi, Mika& Yano, Megumu…[et al.]. Reduced Birth Weight, Decreased Early-Phase Insulin Secretion, and Increased Glucose Concentrations after Oral Glucose Tolerance Test in Japanese Women Aged 20 Years with Family History of Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر