High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBNKob-Leprfafa Rats: A New Model of Type 2 Diabetes Mellitus
المؤلفون المشاركون
Takagi, Yoshiichi
Sugimoto, Taichi
Kobayashi, Masaya
Shirai, Mitsuyuki
Asai, Fumitoshi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial.
We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats.
In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats.
Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks.
Systolic blood pressure and urine volume were increased in WBKDF-HS and Wistar-HS.
Body weight gain and food consumption were comparable between NS and HS in both strains.
Plasma and urine glucose levels were significantly increased in WBKDF-NS but not in WBKDF-HS.
HOMA-IR in WBKDF-HS was significantly lower compared with that in WBKDF-NS.
The high plasma adiponectin level in WBKDF-NS compared with that in Wistar-NS was further enhanced in WBKDF-HS.
Glycogen deposits and fat droplets in the livers of WBKDF-HS were reduced compared with those of WBKDF-NS.
The present study demonstrated that HS intake ameliorated hyperglycemia and insulin resistance in WBKDF rats, which may be due to increased plasma levels of adiponectin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takagi, Yoshiichi& Sugimoto, Taichi& Kobayashi, Masaya& Shirai, Mitsuyuki& Asai, Fumitoshi. 2018. High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBNKob-Leprfafa Rats: A New Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takagi, Yoshiichi…[et al.]. High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBNKob-Leprfafa Rats: A New Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takagi, Yoshiichi& Sugimoto, Taichi& Kobayashi, Masaya& Shirai, Mitsuyuki& Asai, Fumitoshi. High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBNKob-Leprfafa Rats: A New Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر