The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes
المؤلفون المشاركون
Yu, Wei
Wu, Feng
Zhao, Xue
Zhang, Yiding
Guo, Ruixue
Zhang, Fanliang
Shang, Jin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide.
Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients.
Nowadays, more and more studies reveal the relationship between diseases and gut microbial community.
We aimed to explore the alteration in composition and function of the gut microbiome in T2DM patients.
Methods.
A total of 137 patients with diabetes and 179 age- and gender-matched healthy controls selected from the healthy people sample center in the First Affiliated Hospital of Zhengzhou University were divided into the DM group and the Con group, respectively.
We collected their venous blood for laboratory tests and stool samples for 16S rRNA sequencing.
The comparison between the two groups including both composition and function of the gut microbiome is presented.Results.
We found that the α-diversity of bacterial taxa in the DM group had an evident decrease compared to that in the Con group.
At the phylum level, the DM group had an obvious decrease of Bacteroidetes and a marked increase of Proteobacteria, Actinobacteria, and Verrucomicrobia.
At the genus level, Bacteroides and Prevotella decreased the most while Escherichia-Shigella, Lachnospiraceae_incertae_sedis, Subdoligranulum, Enterococcus, and Klebsiella had different degrees of expansion in the DM group.
The ROC based on 246 optimum OTUs had very high test efficiency with an AUC of 92.25% in the training set and 90.48% in the test set.
As for prediction of metabolic function, the gut microbiome of DM patients was predicted to be more active in environmental information processing and human diseases but less in metabolism.
Conclusion.
We observed alteration of composition and function of the gut microbiome in the DM group.
These changes may provide a new treatment strategy for DM patients and new research targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Xue& Zhang, Yiding& Guo, Ruixue& Yu, Wei& Zhang, Fanliang& Wu, Feng…[et al.]. 2020. The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1183485
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Xue…[et al.]. The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1183485
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Xue& Zhang, Yiding& Guo, Ruixue& Yu, Wei& Zhang, Fanliang& Wu, Feng…[et al.]. The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1183485
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183485
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر