Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis
المؤلفون المشاركون
Kikuchi, Takeshi
Mitani, Akio
Sawada, Noritaka
Adachi, Kei
Nakamura, Nobuhisa
Miyabe, Megumi
Ito, Mizuho
Kobayashi, Shuichiro
Miyajima, Shin-ichi
Suzuki, Yuki
Mizutani, Makoto
Toriumi, Taku
Honda, Masaki
Matsubara, Tatsuaki
Naruse, Keiko
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Periodontitis is one of the diabetic complications due to its high morbidity and severity in patients with diabetes.
The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional.
Here, we evaluated the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on the amelioration of periodontitis.
Five-wk-old Male Sprague–Dawley (SD) rats (n=30) were divided into 3 groups: normal, periodontitis, and periodontitis with liraglutide treatment groups.
Periodontitis was induced by ligature around the maxillary second molar in SD rats.
Half of the rats were administered liraglutide for 2 weeks.
Periodontitis was evaluated by histological staining, gene expressions of inflammatory cytokines in gingiva, and microcomputed tomography.
Periodontitis increased inflammatory cell infiltration, macrophage accumulation, and gene expressions of tumor necrosis factor-α and inducible nitric oxide synthase in the gingiva, all of which were ameliorated by liraglutide.
Liraglutide decreased M1 macrophages but did not affect M2 macrophages in periodontitis.
Moreover, ligature-induced alveolar bone resorption was ameliorated by liraglutide.
Liraglutide treatment also reduced osteoclasts on the alveolar bone surface.
These results highlight the beyond glucose-lowering effects of liraglutide on the treatment of periodontitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sawada, Noritaka& Adachi, Kei& Nakamura, Nobuhisa& Miyabe, Megumi& Ito, Mizuho& Kobayashi, Shuichiro…[et al.]. 2020. Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sawada, Noritaka…[et al.]. Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sawada, Noritaka& Adachi, Kei& Nakamura, Nobuhisa& Miyabe, Megumi& Ito, Mizuho& Kobayashi, Shuichiro…[et al.]. Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر