In Vitro Safety Evaluation and In Vivo Imaging Studies of Superparamagnetic Iron Oxide Nanoparticles through Biomimetic Modification
المؤلفون المشاركون
Zhang, Yancong
Sun, Hanwen
Song, Xinfeng
Dong, Pingxuan
Zhang, Zhongyu
Liu, Jing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Magnetic resonance imaging (MRI) is an advanced medical imaging diagnostic technique that utilizes different resonance signals generated by the signal strength of water content and the relaxation time of protons in water molecules under the influence of an external magnetic field.
This technique requires contrast agents, such as Gd-DTPA and Gd-DOTA, which could increase the risk of renal fibrosis in patients with severe renal insufficiency.
The magnetic moment or susceptibility of superparamagnetic iron oxide nanoparticle (SPION) is higher than that of other paramagnetic substances and could significantly reduce the dosage of the contrast agent required.
In our previous work, the novel magnetic composite nanoparticles (abbreviated as c(RGDyK)-PDA-SPION) had been successfully synthesized by a facile and simple approach.
Further evaluation had demonstrated that it had an average particle size of about 50 nm and uniform distribution, superparamagnetic properties, and good dispersion stability in water solution.
Animal acute toxicity test also had proved that it had high safety in vivo.
In this work, c(RGDyK)-PDA-SPION was further studied for the cell toxicity and effect on HepG2 cells in vitro, and the MRI imaging of this contrast agent in HepG2 tumor-bearing mice was also studied.
It is an extension of the published work.
The results showed that it possessed high safety and enrichment phenomenon on HepG2 cells in vitro.
Animal experimental data preliminarily prove that the contrast agent could enhance the MRI T2-weighted imaging capability of HepG2 carcinoma in tumor-bearing mice and could be a potential T2 contrast agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Xinfeng& Zhang, Yancong& Sun, Hanwen& Dong, Pingxuan& Zhang, Zhongyu& Liu, Jing. 2019. In Vitro Safety Evaluation and In Vivo Imaging Studies of Superparamagnetic Iron Oxide Nanoparticles through Biomimetic Modification. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Xinfeng…[et al.]. In Vitro Safety Evaluation and In Vivo Imaging Studies of Superparamagnetic Iron Oxide Nanoparticles through Biomimetic Modification. Journal of Nanomaterials No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1183492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Xinfeng& Zhang, Yancong& Sun, Hanwen& Dong, Pingxuan& Zhang, Zhongyu& Liu, Jing. In Vitro Safety Evaluation and In Vivo Imaging Studies of Superparamagnetic Iron Oxide Nanoparticles through Biomimetic Modification. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر