Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance
المؤلفون المشاركون
Shao, Xinyu
Shi, Bimin
Du, Xuan
Lu, Wen
Lu, Zijun
Hu, Chunhong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
To study the effectiveness of exenatide with metformin and sequential treatment with exenatide and glargine added to metformin and their influence on insulin sensitivity and adipose distribution.
Methods.
20 newly diagnosed obese type 2 diabetic patients were enrolled, and 2-month washout treatment of metformin, 6-month exenatide treatment, and 6-month glargine treatment were administrated sequentially accompanied with previous metformin.
Glucolipid metabolic parameters were compared among groups.
Adipose distribution was quantified with computerized tomography according to anatomy, dividing into visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), adding up to total adipose tissue (TAT).
Results.
The 6-month exenatide treatment dramatically ameliorated the glucose and lipid profile, improved insulin sensitivity, and mainly decreased VAT and also the ratio of VAT/SAT (RVS).
The following 6-month glargine treatment increased VAT.
The whole 12-month sequential treatment with exenatide and glargine added to metformin basically improved the insulin sensitivity and glucolipid control though VAT rebounded at the end, however without deteriorating the other parameters.
Conclusion.
Exenatide is an ideal treatment for obese type 2 diabetic patients in the aspect of adipose tissue distribution.
Sequential treatment of exenatide and glargine could be an alternative for low-income patients who cannot afford GLP-1 agonist for long time.
This trial is registered with ChiCTR-OOC-17013679.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Du, Xuan& Lu, Wen& Lu, Zijun& Shao, Xinyu& Hu, Chunhong& Shi, Bimin. 2018. Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183497
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Du, Xuan…[et al.]. Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance. Journal of Diabetes Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1183497
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Du, Xuan& Lu, Wen& Lu, Zijun& Shao, Xinyu& Hu, Chunhong& Shi, Bimin. Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183497
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183497
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر