Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Liu, Shu-Jung
Chang, Yu-Chen
Lin, Chien-Ju
Hsiao, Yu-Hsuan
Chang, Yu-Han
Hsu, Hsin-Yin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Type 1 diabetes mellitus (T1DM) causes the irreversible destruction of pancreatic beta cells.
The Bacillus Calmette–Guerin (BCG) vaccine can modulate the immune response and decelerate disease progression.
The aim of this study is to investigate the efficacy of the BCG vaccine for the treatment of T1DM.
Objective.
Six databases were systematically searched from inception to the end of August 2019.
The randomized controlled trials (RCTs) that evaluated glycemic control in response to the BCG vaccine for T1DM were enrolled.
The primary outcome was glycated hemoglobin (HbA1c) level, and secondary outcomes included fasting and stimulated C-peptide level, daily insulin dosage, and clinical remission.
The revised Cochrane risk of bias tool was used for quality assessment, and meta-analyses were conducted to evaluate the efficacy of the BCG vaccine.
Results.
Four studies with a total of 198 subjects were included.
The results of HbA1c and fasting C-peptide levels were extracted for further quantitative assessment.
The pooled meta-analysis demonstrated no significant difference in HbA1c levels (mean difference [MD], −0.12; 95% confidence interval [CI], −0.53 to 0.30; I2=56%) or fasting C-peptide levels (MD, −0.15; 95% CI, −0.35 to 0.06; I2=0%) in the BCG intervention group as compared with that in the placebo group.
Conclusions.
There is no robust evidence to support the use of the BCG vaccine for the treatment of T1DM although the HbA1c levels tended to improve.
Additional RCTs to assess the long-term effects of the BCG vaccine on glycemic control are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Yu-Chen& Lin, Chien-Ju& Hsiao, Yu-Hsuan& Chang, Yu-Han& Liu, Shu-Jung& Hsu, Hsin-Yin. 2020. Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Yu-Chen…[et al.]. Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Diabetes Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1183508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Yu-Chen& Lin, Chien-Ju& Hsiao, Yu-Hsuan& Chang, Yu-Han& Liu, Shu-Jung& Hsu, Hsin-Yin. Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر