Exendin-4 Improves Diabetic Kidney Disease in C57BL6 Mice Independent of Brown Adipose Tissue Activation
المؤلفون المشاركون
Guan, Meiping
Wang, Ling
Xue, Yaoming
Zeng, Yanmei
Fang, Shu
Cai, Yingying
Lyu, Fuping
Zhang, Hongbin
Wu, Chunyan
Fan, Cunxia
Zou, Shaozhou
Zhang, Yudan
Li, Ping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
The role of exendin-4 in brown adipose tissue (BAT) activation was not very clear.
This study is to verify the role of BAT involved in renal benefits of exendin-4 in diabetes mellitus (DM).
Methods.
In vivo, C57BL/6 mice were randomly divided into nondiabetic (control) and diabetic groups (DM).
The diabetic mice were randomized into a control group (DM-Con), BAT-excision group (DM+Exc), exendin-4-treated group (DM+E4), and BAT-excision plus exendin-4-treated group (DM+Exc+E4).
The weight, blood glucose and lipids, 24 h urine albumin and 8-OH-dG, and renal fibrosis were analyzed.
In vitro, we investigated the role of exendin-4 in the differentiation process of 3T3-L1 and brown preadipocytes and its effect on the rat mesangial cells induced by oleate.
Results.
The expressions of UCP-1, PGC-1α, ATGL, and CD36 in BAT of DM mice were all downregulated, which could be upregulated by exendin-4 treatment with significant effects on ATGL and CD36.
BAT-excision exacerbated high blood glucose (BG) with no significant effect on the serum lipid level.
Exendin-4 significantly lowered the level of serum triglycerides (TG) and low-density lipoprotein- (LDL-) c, 24 h urine albumin, and 8-OH-dG; improved renal fibrosis and lipid accumulation; and activated renal AMP-activated protein kinase (AMPK) in diabetic mice regardless of BAT excision.
In vitro, there was no significant effect of exendin-4 on brown or white adipogenesis.
However, exendin-4 could improve lipid accumulation and myofibroblast-like phenotype transition of mesangial cells induced by oleate via activating the AMPK pathway.
Conclusions.
Exendin-4 could decrease the renal lipid deposit and improve diabetic nephropathy via activating the renal AMPK pathway independent of BAT activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fang, Shu& Cai, Yingying& Lyu, Fuping& Zhang, Hongbin& Wu, Chunyan& Zeng, Yanmei…[et al.]. 2020. Exendin-4 Improves Diabetic Kidney Disease in C57BL6 Mice Independent of Brown Adipose Tissue Activation. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fang, Shu…[et al.]. Exendin-4 Improves Diabetic Kidney Disease in C57BL6 Mice Independent of Brown Adipose Tissue Activation. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fang, Shu& Cai, Yingying& Lyu, Fuping& Zhang, Hongbin& Wu, Chunyan& Zeng, Yanmei…[et al.]. Exendin-4 Improves Diabetic Kidney Disease in C57BL6 Mice Independent of Brown Adipose Tissue Activation. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر