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Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTENPI3KAkt Signaling Pathway
المؤلفون المشاركون
Li, Dong
Song, Yanyan
Liu, Wei
Tang, Ke
Zang, Junting
Gao, Hang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Renal interstitial fibrosis is considered to be the typical manifestation of diabetic nephropathy (DN).
Mangiferin has shown positive effect on the prevention or treatment of diabetes and its complications.
The aim of this study was to explore the inhibitive effect and mechanism of mangiferin on renal interstitial fibrosis in diabetic mice.
Streptozotocin- (STZ-) induced diabetic mice were treated with mangiferin (15, 30, and 60 mg/kg/d) for 4 weeks.
The morphology of kidneys was observed by Masson’s trichrome staining, and the biochemical parameters (fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), serum creatinine (SCr), and urine protein) were determined by kits.
In addition, the levels of inflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin- (IL-) 6, and IL-1β), antioxidant enzymes (SOD, CAT, and GSH-Px), MDA, and ROS were assessed.
Furthermore, the expressions of fibronectin (FN), collagen I (Col I), and α-SMA were measured by immunohistochemistry.
Regulations of TGF-β1 and the PTEN/PI3K/Akt pathway were detected by Western blotting.
Treatment with mangiferin significantly ameliorated renal dysfunction in diabetic mice, as evidenced by the increase in body weight and decreases in FBG, TG, TC, BUN, SCr, urine protein, and the kidney to body weight ratio (KW/BW).
Furthermore, mangiferin treatment prevented renal interstitial fibrosis evidenced by decreases in the positive expression of FN, Col I, and α-SMA, in comparison with morphological changes in the renal tissue.
Meanwhile, mangiferin increased antioxidant enzymes, reduced the TNF-α, IL-6, and IL-1β, as well as MDA and ROS.
Additionally, mangiferin administration also downregulated TGF-β1, upregulated PTEN, and decreased the phosphorylation of both PI3K and Akt.
These findings demonstrate that mangiferin may reduce inflammation and oxidative stress in DN, thereby inhibiting the renal interstitial fibrosis by reducing the TGF-β1-mediated elevation of Col I, FN, and α-SMA through the PTEN/PI3K/Akt pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Yanyan& Liu, Wei& Tang, Ke& Zang, Junting& Li, Dong& Gao, Hang. 2020. Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTENPI3KAkt Signaling Pathway. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183563
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Yanyan…[et al.]. Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTENPI3KAkt Signaling Pathway. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183563
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Yanyan& Liu, Wei& Tang, Ke& Zang, Junting& Li, Dong& Gao, Hang. Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTENPI3KAkt Signaling Pathway. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183563
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183563
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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