Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus
المؤلفون المشاركون
Zhu, Xiangyun
Lin, Hao
Zhu, Huimin
Liu, Dechen
Dai, Yu
Su, Xianghui
Li, Ling
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas.
Recent studies revealed increased serum PSP/REG Iα levels may reflect renal dysfunction.
The purpose of this study was to detect the relationship between PSP/REG Iα and renal function in subjects with and without type 2 diabetes mellitus (T2DM).
Methods.
This cross-sectional study was conducted at Zhongda Hospital, affiliated with Southeast University in China.
Serum PSP/REG Iα levels were measured using a method of enzyme-linked immunosorbent assay.
Baseline characteristics and biochemical parameters, such as blood urea nitrogen (BUN), serum creatinine (SCr), and uric acid (UA), were collected.
The estimated glomerular filtration rate (eGFR) of each individual was calculated using the diagnostic criteria for renal function.
Correlations between PSP/REG Iα and renal function parameters were analyzed by Spearman’s rank correlation coefficient using SPSS 20.0 software.
Results.
Serum PSP/REG Iα levels were significantly higher in T2DM patients than those without T2DM (P<0.05).
The level of PSP/REG Iα was positively correlated with age, SCr, and BUN and negatively correlated with eGFR.
The ordinal multiple logistic regression analysis further illustrated that PSP/REG Iα levels were negatively related with eGFR in both groups after adjusting for other parameters.
Conclusions.
Serum PSP/REG Iα level is significantly upregulated in T2DM patients and reflects renal function in both T2DM and nondiabetic control groups.
The relationship between PSP/REG Iα and eGFR suggested that PSP/REG Iα might be a potential indicator of renal dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Huimin& Zhu, Xiangyun& Lin, Hao& Liu, Dechen& Dai, Yu& Su, Xianghui…[et al.]. 2020. Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183597
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Huimin…[et al.]. Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1183597
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Huimin& Zhu, Xiangyun& Lin, Hao& Liu, Dechen& Dai, Yu& Su, Xianghui…[et al.]. Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183597
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183597
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر