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Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus
Joint Authors
Zhu, Xiangyun
Lin, Hao
Zhu, Huimin
Liu, Dechen
Dai, Yu
Su, Xianghui
Li, Ling
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas.
Recent studies revealed increased serum PSP/REG Iα levels may reflect renal dysfunction.
The purpose of this study was to detect the relationship between PSP/REG Iα and renal function in subjects with and without type 2 diabetes mellitus (T2DM).
Methods.
This cross-sectional study was conducted at Zhongda Hospital, affiliated with Southeast University in China.
Serum PSP/REG Iα levels were measured using a method of enzyme-linked immunosorbent assay.
Baseline characteristics and biochemical parameters, such as blood urea nitrogen (BUN), serum creatinine (SCr), and uric acid (UA), were collected.
The estimated glomerular filtration rate (eGFR) of each individual was calculated using the diagnostic criteria for renal function.
Correlations between PSP/REG Iα and renal function parameters were analyzed by Spearman’s rank correlation coefficient using SPSS 20.0 software.
Results.
Serum PSP/REG Iα levels were significantly higher in T2DM patients than those without T2DM (P<0.05).
The level of PSP/REG Iα was positively correlated with age, SCr, and BUN and negatively correlated with eGFR.
The ordinal multiple logistic regression analysis further illustrated that PSP/REG Iα levels were negatively related with eGFR in both groups after adjusting for other parameters.
Conclusions.
Serum PSP/REG Iα level is significantly upregulated in T2DM patients and reflects renal function in both T2DM and nondiabetic control groups.
The relationship between PSP/REG Iα and eGFR suggested that PSP/REG Iα might be a potential indicator of renal dysfunction.
American Psychological Association (APA)
Zhu, Huimin& Zhu, Xiangyun& Lin, Hao& Liu, Dechen& Dai, Yu& Su, Xianghui…[et al.]. 2020. Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183597
Modern Language Association (MLA)
Zhu, Huimin…[et al.]. Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1183597
American Medical Association (AMA)
Zhu, Huimin& Zhu, Xiangyun& Lin, Hao& Liu, Dechen& Dai, Yu& Su, Xianghui…[et al.]. Association of Serum PSPREG Iα with Renal Function in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183597