AgNPs and AgC225 Exert Anticancerous Effects via Cell Cycle Regulation and Cytotoxicity Enhancement
المؤلفون المشاركون
Zhang, Yan
Lu, Hong
Yu, Dahai
Zhao, Di
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Currently, cancer has become the leading cause of deaths and is a serious threat to human health.
Nanotechnology-based medical applications are developing rapidly, especially in anticancer research, as nanomaterials can be retained in the cell after their entry across the cell membrane, making them potential candidates for application in the diagnosis and treatment of tumours.
Here, we prepared silver nanoparticles (AgNPs) and silver/cetuximab (Ag/C225) particles of approximately 20 nm and investigated their inhibitory effect on proliferation of human nasopharyngeal carcinoma cell line CNE and laryngeal carcinoma cell line HEp-2.
The MTT assay was used to determine their half-maximal inhibitory concentration (IC50) values.
Electron microscopy revealed no obvious morphological differences between the prepared AgNPs and Ag/C225.
Treatment of both cell lines with AgNPs and Ag/C225 increased the proportion of cells in the G0/G1 stage and decreased the proportion of cells in the S stage.
AgNP and Ag/C225 treatments increased the expression of apoptotic proteins Bax and P21 and decreased the expression of Bcl-2 in CNE cells, compared to control cells.
Ag/C225 is internalised by CNE cells, and it enhances X-irradiation-induced cytotoxicity.
These results help increase the understanding of the anticancer effect of AgNPs and Ag/C225 and explore their application as radiosensitisers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yan& Lu, Hong& Yu, Dahai& Zhao, Di. 2017. AgNPs and AgC225 Exert Anticancerous Effects via Cell Cycle Regulation and Cytotoxicity Enhancement. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1183616
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yan…[et al.]. AgNPs and AgC225 Exert Anticancerous Effects via Cell Cycle Regulation and Cytotoxicity Enhancement. Journal of Nanomaterials No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1183616
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yan& Lu, Hong& Yu, Dahai& Zhao, Di. AgNPs and AgC225 Exert Anticancerous Effects via Cell Cycle Regulation and Cytotoxicity Enhancement. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1183616
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183616
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر