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Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss
المؤلف
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The purpose of this study was to compare systemic inflammation in older women with a history of gestational diabetes (GDM) who developed impaired glucose tolerance (IGT) or type 2 diabetes (T2DM) to that in those with normal glucose tolerance (NGT) and to determine, in these women, the effect of weight loss (WL) induced by diet and exercise training on systemic inflammation and adipokine levels.
This was a longitudinal clinical investigation of overweight/obese (BMI: 32 ± 1 kg/m2) women (59 ± 1 years) with a GDM history (n=19) who had normal glucose tolerance (NGT, n=7) or IGT/T2DM (n=12).
Women completed 6 months of weight loss induced by diet and exercise and underwent VO2max, body composition, blood draw, glucose tolerance testing, and 2-hour hyperinsulinemic-euglycemic clamps (40 mU·m−2·min−1).
Glucose utilization (M) was 42% higher in the NGT group (P<0.05).
CRP was two-fold higher in the IGT/T2DM group than that in the NGT group (P<0.01).
Adiponectin levels were 59% higher in the NGT group than those in the IGT/T2DM group (P<0.01).
IL-6sR was higher in the NGT group (P<0.01).
The women lost body weight, body fat, visceral fat, and subcutaneous abdominal fat (P<0.001).
Fasting glucose (P<0.05), fasting insulin, glucose, and insulin AUC decreased (all P<0.005) after the intervention.
M increased by 21% (P<0.05).
CRP (−16%) and TNFR1 (−6%) tended to decrease, whereas TNFα, IL-6, SAA, and adiponectin did not change in the group.
In conclusion, older women with a history of GDM who have developed IGT or T2DM have higher CRP and reduced adiponectin levels despite similar BMI and total and abdominal obesity to those with NGT.
Six months WL induced by diet and exercise improves body composition and increases insulin sensitivity without a significant modification of inflammatory markers and adiponectin levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ryan, Alice S.. 2018. Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1183658
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ryan, Alice S.. Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss. Journal of Diabetes Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1183658
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ryan, Alice S.. Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1183658
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183658
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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