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Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats
المؤلفون المشاركون
Amaral, Liliany Souza de Brito
Soares, Telma de Jesus
Souza, Cláudia Silva
Volpini, Rildo Aparecido
Shimizu, Maria Heloisa Massola
de Bragança, Ana Carolina
Canale, Daniele
Seguro, Antonio Carlos
de Magalhães, Amélia Cristina Mendes
Coimbra, Terezila M.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats.
For this purpose, Wistar rats were divided into five groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD), and previously trained diabetic (PTD).
Only the PTD group was submitted to treadmill running for 4 weeks previously to DM induction with streptozotocin (40 mg/kg, i.v).
After confirming diabetes, the PTD, TD, and TC groups were submitted to eight weeks of exercise training.
At the end of the training protocol, we evaluated the following: glycosuria, body weight gain, plasma, renal and urinary levels of nitric oxide and thiobarbituric acid reactive substances, renal glutathione, and immunolocalization of lymphocytes, macrophages, and nuclear factor-kappa B (NF-κB/p65) in the renal cortex.
The results showed that exercise training reduced glycosuria, renal TBARS levels, and the number of immune cells in the renal tissue of the TD and PTD groups.
Of note, only previous exercise increased weight gain and urinary/renal NO levels and reduced NF-κB (p65) immunostaining in the renal cortex of the PTD group.
In conclusion, our study shows that exercise training, especially when initiated previously to diabetes induction, promotes protective effects in diabetic kidney by reduction of renal oxidative stress and inflammation markers in female Wistar rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amaral, Liliany Souza de Brito& Souza, Cláudia Silva& Volpini, Rildo Aparecido& Shimizu, Maria Heloisa Massola& de Bragança, Ana Carolina& Canale, Daniele…[et al.]. 2018. Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amaral, Liliany Souza de Brito…[et al.]. Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats. Journal of Diabetes Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1183756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amaral, Liliany Souza de Brito& Souza, Cláudia Silva& Volpini, Rildo Aparecido& Shimizu, Maria Heloisa Massola& de Bragança, Ana Carolina& Canale, Daniele…[et al.]. Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1183756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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