Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs
المؤلفون المشاركون
Al-Mashhadi, Ahmed Ludvigsen
Poulsen, Christian Bo
von Wachenfeldt, Karin
Robertson, Anna-Karin
Bentzon, Jacob Fog
Nielsen, Lars Bo
Thygesen, Jesper
Tolbod, Lars Poulsen
Larsen, Jens Rolighed
Moestrup, Søren Kragh
Frendéus, Björn
Mortensen, Brynjulf
Drouet, Ludovic
Al-Mashhadi, Rozh H.
Falk, Erling
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive.
Animal models resembling human MetS and its complications, while important, are scarce.
We aimed at developing a porcine model of human MetS.
Methods.
Forty pigs with familial hypercholesterolemia were fed a high fat + fructose diet for 30 weeks.
Metabolic assessments and subcutaneous fat biopsies were obtained at 18 and 30 weeks, and fat distribution was assessed by CT-scans.
Postmortem, macrophage density, and phenotype in fat tissues were quantified along with atherosclerotic burden.
Results.
During the experiment, we observed a >4-fold in body weight, a significant but small increase in fasting glucose (4.1 mmol/L), insulin (3.1 mU/L), triglycerides (0.5 mmol/L), and HDL cholesterol (2.6 mmol/L).
Subcutaneous fat correlated with insulin resistance, but intra-abdominal fat correlated inversely with insulin resistance and LDL cholesterol.
More inflammatory macrophages were found in visceral versus subcutaneous fat, and inflammation decreased in subcutaneous fat over time.
Conclusions.
MetS based on human criteria was not achieved.
Surprisingly, visceral fat seemed part of a healthier metabolic and inflammatory profile.
These results differ from human findings, and further research is needed to understand the relationship between obesity and MetS in porcine models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Mashhadi, Ahmed Ludvigsen& Poulsen, Christian Bo& von Wachenfeldt, Karin& Robertson, Anna-Karin& Bentzon, Jacob Fog& Nielsen, Lars Bo…[et al.]. 2018. Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183811
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Mashhadi, Ahmed Ludvigsen…[et al.]. Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs. Journal of Diabetes Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1183811
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Mashhadi, Ahmed Ludvigsen& Poulsen, Christian Bo& von Wachenfeldt, Karin& Robertson, Anna-Karin& Bentzon, Jacob Fog& Nielsen, Lars Bo…[et al.]. Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183811
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183811
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر