Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions
المؤلفون المشاركون
Pontremoli, Roberto
Ceriello, Antonio
Giorda, Carlo
Guida, Pietro
Study Group, AMD-Annals
Gentile, Sandro
Piscitelli, Pamela
Fioretto, Paola
De Cosmo, Salvatore
Viazzi, Francesca
Russo, Giuseppina T.
Strollo, Felice
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We performed a real-life analysis of clinical and laboratory parameters, in orally treated T2DM patients aiming at identifying predictors of insulin treatment initiation.
Overall, 366955 patients (55.8% males, age 65 ± 11 years, diabetes duration 7 ± 8 years) were followed up between 2004 and 2011.
Each patient was analyzed step-by-step until either eventually starting insulin treatment or getting to the end of the follow-up period.
Patients switching to insulin showed a worse global risk profile, longer disease duration (10 ± 9 years vs.
6 ± 7 years, respectively; p<0.001), higher HbA1c (8.0 ± 1.6% vs.
7.2 ± 1.5%, respectively; p<0.001), higher triglycerides, a greater prevalence of arterial hypertension, antihypertensive, lipid-lowering and aspirin treatment, a higher rate of nonproliferative/proliferative retinopathy, and a nearly 4 times lower prevalence of the “diet alone.” They also showed a higher prevalence of subjects with eGFR < 60 ml/min/1.73 m2 (24.0% vs.
16.2%, respectively; p<0.001).
Multivariate analysis identified diabetes duration, HbA1c, triglyceride and low HDL-C values, presence of retinopathy or renal dysfunction, and sulphonylurea utilization (the risk being approximately 3 times greater in the latter case) as independent predictors of insulin treatment initiation.
LDL-C, lipid-lowering treatment, and overweight/obese seem to be protective.
Results of tree analysis showed that patients on sulphonylurea, with high HbA1c, eGFR below 50 ml/min/1.73 m2, and at least 5-year disease duration, are at very high risk to start insulin treatment.
We have to stick to this real-life picture, of course, until enough data are collected on patients treated with innovative medications which are expected to improve beta cell survival and further delay treatment-related insulin requirement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gentile, Sandro& Strollo, Felice& Viazzi, Francesca& Russo, Giuseppina T.& Piscitelli, Pamela& Ceriello, Antonio…[et al.]. 2018. Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183827
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gentile, Sandro…[et al.]. Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions. Journal of Diabetes Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1183827
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gentile, Sandro& Strollo, Felice& Viazzi, Francesca& Russo, Giuseppina T.& Piscitelli, Pamela& Ceriello, Antonio…[et al.]. Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183827
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183827
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر