The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers
المؤلفون المشاركون
Sibiya, Ntethelelo Hopewell
Ngubane, Phikelelani
Khathi, Andile
Siboto, Anelisiwe
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Studies suggest that Momordica balsamina (intshungu) possesses hypoglycaemic effects.
The effects of Momordica balsamina on diabetic complications such as DN, however, have not been established.
Accordingly, this study seeks to investigate the effects of M.
balsamina on kidney function in STZ-induced diabetic rats.
Methods.
Methanolic extracts (ME) of M.
balsamina’s leaves were used in this study.
Short-term effects of M.
balsamina methanolic extract on kidney function and MAP were studied in STZ-induced diabetic rats treated twice daily with M.
balsamina methanolic extract (250 mg/kg), insulin (175 μg/kg, s.c.), and metformin (500 mg/kg) for 5 weeks.
Results.
M.
balsamina methanolic extract significantly increased Na+ excretion outputs in STZ-induced diabetic rats by comparison to STZ-diabetic control rats.
M.
balsamina methanolic extract significantly increased GFR in STZ-diabetic rats with a concomitant decrease in creatinine concentration and also reduced kidney-to-body ratio, albumin excretion rate (AER), and albumin creatinine ratio (ACR).
M.
balsamina methanolic extract significantly reduced MAP in STZ-diabetic animals by comparison with STZ-diabetic control animals.
These results suggest that M.
balsamina methanolic extract not only lowers blood glucose but also has beneficial effects on kidney function and blood pressure.
Conclusion.
These findings suggest that M.
balsamina may have beneficial effects on some processes that are associated with renal derangement in STZ-induced diabetic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siboto, Anelisiwe& Sibiya, Ntethelelo Hopewell& Khathi, Andile& Ngubane, Phikelelani. 2018. The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siboto, Anelisiwe…[et al.]. The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siboto, Anelisiwe& Sibiya, Ntethelelo Hopewell& Khathi, Andile& Ngubane, Phikelelani. The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر