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A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell
المؤلفون المشاركون
Sun, Zilin
Shi, Ruifeng
Zhou, Yunting
Wang, Xiaohang
Li, Wei
Chen, Juan
Zhao, Sheng
Qiu, Shanhu
Yin, Han
Carvalho, Vladmir
Hu, Jiannan
Li, Shenyi
Nijiati, Munire
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Our previous studies have shown that islet stellate cell (ISC), similar to pancreatic stellate cell (PSC) in phenotype and biological characters, may be responsible for the islet fibrosis in type 2 diabetes.
To further identify the differences between PSC and ISC and for better understanding of the physiological function of ISC, we employed genome-wide transcriptional analysis on the PSCs and ISCs of Wistar rats.
Method.
PSCs and ISCs from each rat were primarily cultured at the same condition.
Genome-wide transcriptional sequence of stellate cells was generated.
The identified differentially expressed genes were validated using RT-PCR.
Results.
32 significant differentially expressed genes between PSCs and ISCs were identified.
Moreover, collagen type 11a1 (COL11A1), was found to be expressed 2.91-fold higher in ISCs compared with PSCs, indicating that COL11A1 might be a potential key gene modulating the differences between PSC and ISC.
Conclusions.
Our study identified and validated the differences between PSC and ISC in genome-wide transcriptional scale, confirming the assumption that ISC and PSC are similar other than identical.
Moreover, our data might be instrumental for further investigation of ISC and islet fibrosis, and some differential expressed genes may provide an insight into new therapeutic targets for type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiaohang& Li, Wei& Chen, Juan& Zhao, Sheng& Qiu, Shanhu& Yin, Han…[et al.]. 2018. A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183849
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiaohang…[et al.]. A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183849
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiaohang& Li, Wei& Chen, Juan& Zhao, Sheng& Qiu, Shanhu& Yin, Han…[et al.]. A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183849
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183849
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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