The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression
المؤلفون المشاركون
Vergara, Daniele
Simeone, Pasquale
Damato, Marina
Maffia, Michele
Lanuti, Paola
Trerotola, Marco
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-20
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
With the advent of novel molecular platforms for high-throughput/next-generation sequencing, the communities of commensal and pathogenic microorganisms that inhabit the human body have been defined in depth.
In the last decade, the role of microbiota-host interactions in driving human cancer plasticity and malignant progression has been well documented.
Germ-free preclinical models provided an invaluable tool to demonstrate that the human microbiota can confer susceptibility to various types of cancer and can also modulate the host response to therapeutic treatments.
Of interest, besides the detrimental effects of dysbiosis on cancer etiopathogenesis, specific microorganisms have been shown to exert protective activities against cancer growth.
This has strong clinical implications, as restoration of the physiologic microbiota is being rapidly implemented as a novel anticancer therapeutic strategy.
Here, we reviewed past and recent literature depicting the role of microbiota-host interactions in modulating key molecular mechanisms that drive human cancer plasticity and lead to malignant progression.
We analyzed microbiota-host interactions occurring in the gut as well as in other anatomic sites, such as oral and nasal cavities, lungs, breast, esophagus, stomach, reproductive tract, and skin.
We revealed a common ground of biological alterations and pathways modulated by a dysbiotic microbiota and potentially involved in the control of cancer progression.
The molecular mechanisms most frequently affected by the pathogenic microorganisms to induce malignant progression involve epithelial-mesenchymal transition- (EMT-) dependent barrier alterations and tumor-promoting inflammation.
This evidence may pave the way to better stratify high-risk cancer patients based on unique microenvironmental/microbial signatures and to develop novel, personalized, biological therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vergara, Daniele& Simeone, Pasquale& Damato, Marina& Maffia, Michele& Lanuti, Paola& Trerotola, Marco. 2019. The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression. Journal of Oncology،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1183898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vergara, Daniele…[et al.]. The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression. Journal of Oncology No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1183898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vergara, Daniele& Simeone, Pasquale& Damato, Marina& Maffia, Michele& Lanuti, Paola& Trerotola, Marco. The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1183898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر