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Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROSTXNIPNLRP3 Inflammasome Pathway
المؤلفون المشاركون
Lu, Li
Lu, Qianyi
Chen, Wei
Li, Jingwen
Li, Chunxia
Zheng, Zhi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
This study aimed to evaluate the mechanisms underlying the effects of 1,25-dihydroxyvitamin D (vitamin D3) on diabetes-induced retinal vascular damage and retinal vascular endothelial cell apoptosis.
Methods.
Diabetic and control rats were randomly assigned to receive vitamin D3 or vehicle for 6 months.
Additionally, human retinal microvascular endothelial cells (HRMECs) were incubated in normal or high-glucose medium with or without vitamin D3.
Morphological changes in retinal tissues and retinal vascular permeability were examined, and cellular apoptosis was detected by fluorescence staining.
Intracellular reactive oxygen species (ROS) levels were determined using fluorescent probes.
Proteins were examined by Western blotting.
Results.
Vitamin D3 significantly downregulated intracellular ROS and inhibited TRX-interacting protein (TXNIP)/NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathway activation.
Additionally, vitamin D3 reduced vascular endothelial growth factor (VEGF) expression and the Bax/Bcl-2 ratio.
These changes were associated with retinal recovery and with decreases in retinal vascular permeability and retinal capillary cell apoptosis.
Conclusions.
Vitamin D3 decreases diabetes-induced ROS and exerts protective effects against retinal vascular damage and cell apoptosis in association with inhibition of the ROS/TXNIP/NLRP3 inflammasome pathway.
Understanding the mechanisms of action of vitamin D3 has important implications for preventing and treating inflammatory-related illnesses such as diabetic retinopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Li& Lu, Qianyi& Chen, Wei& Li, Jingwen& Li, Chunxia& Zheng, Zhi. 2018. Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROSTXNIPNLRP3 Inflammasome Pathway. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183936
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Li…[et al.]. Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROSTXNIPNLRP3 Inflammasome Pathway. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1183936
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Li& Lu, Qianyi& Chen, Wei& Li, Jingwen& Li, Chunxia& Zheng, Zhi. Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROSTXNIPNLRP3 Inflammasome Pathway. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183936
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183936
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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