Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism
المؤلفون المشاركون
Scola, Letizia
Anna, Giammanco
Mascarella, Chiara
Capra, Giuseppina
Serra, Nicola
Gagliardi, Cesare
Cannella, Sara
Simonte, Maria Rosa
Lipari, Dario
Sciortino, Miriam
Di Carlo, Paola
Fasciana, Teresa
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Helicobacter pylori and Epstein–Barr virus (EBV) infection have recently been shown to be associated with gastric diseases.
Polymorphisms in genes encoding cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN) influence cytokine secretion levels and appear to contribute to the risk of developing gastroduodenal diseases.
To our knowledge, this is the first preliminary study to address the association of coinfection with H.
pylori and EBV and their correlation with genetic predisposition in the development of gastric diseases.
Methods.
Gastric biopsy samples of 96 patients with different gastric diseases were used.
Results.
Our results showed that the rate of coinfection was higher in patients with gastric cancer than in patients with normal gastric mucosa, active chronic gastritis, and MALT lymphoma.
As regards the characterization of H.
pilory strains, the polymorphism s1m1i1 of vacA gene was more frequent in patients with MALT Lymphoma in comparison to others, while the polymorphism s2m2i2 was most frequent in patients with normal gastric mucosa.
In addition, patients who tested positive for the cagA gene were more frequently those affected with gastric cancer than those with inactive chronic gastritis.
Similarly, the patients with oipA gene ON were more frequently those with gastric cancer than those with inactive chronic gastritis.
Conclusion.
According to our analysis, there was no correlation between coinfection and polymorphisms in genes encoding IL-10 and IL-1RN.
We conclude that various factors can be involved in the development of gastric diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fasciana, Teresa& Serra, Nicola& Capra, Giuseppina& Mascarella, Chiara& Gagliardi, Cesare& Di Carlo, Paola…[et al.]. 2019. Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fasciana, Teresa…[et al.]. Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1183976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fasciana, Teresa& Serra, Nicola& Capra, Giuseppina& Mascarella, Chiara& Gagliardi, Cesare& Di Carlo, Paola…[et al.]. Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر