Association of ESR1 Mutations and Visceral Metastasis in Patients with Estrogen Receptor-Positive Advanced Breast Cancer from Brazil
المؤلفون المشاركون
Reinert, Tomás
Coelho, Guilherme Portela
Mandelli, Jovana
Zimermann, Edinéia
Zaffaroni, Facundo
Bines, José
Barrios, Carlos Henrique
Graudenz, Marcia Silveira
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Mutations in the ESR1 gene (ESR1m) are important mechanisms of resistance to endocrine therapy in estrogen receptor-positive advanced breast cancer and have been recognized as a prognostic and predictive biomarker as well as a potential therapeutic target.
However, the prevalence of ESR1m in real-world patients has not been adequately described.
Therefore, we sought to evaluate the prevalence of ESR1m in metastatic samples from Brazilian patients with estrogen receptor-positive (ER+) advanced breast cancer previously treated with endocrine therapy.
The presence of ESR1m was evaluated in formalin-fixed paraffin-embedded (FFPE) breast cancer tissue using real-time quantitative polymerase chain reaction (RT-qPCR).
Mutations in codons 380, 537, and 538 of the ESR1 gene were analyzed.
Out of 77 breast cancer samples, 11 (14.3%) showed mutations in the ESR1 gene.
ESR1m were detected in a variety of organs, and the D538G substitution was the most common mutation.
In visceral metastasis, ESR1m were detected in 25% (8/32) of the samples, whereas in nonvisceral metastasis, ESR1m were detected in 6.7% (3/45) of the samples.
The odds of a sample with visceral metastasis having an ESR1 mutation is 4.66 times the odds of a sample of nonvisceral metastasis having an ESR1 mutation (95% CI: 1.13–19.27; p value = 0.0333).
Our study indicates that the prevalence of ESR1m in samples from Brazilian patients with metastatic ER+ breast cancer is similar to that described in patients included in clinical trials.
We observed an association of ESR1m with visceral metastasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reinert, Tomás& Coelho, Guilherme Portela& Mandelli, Jovana& Zimermann, Edinéia& Zaffaroni, Facundo& Bines, José…[et al.]. 2019. Association of ESR1 Mutations and Visceral Metastasis in Patients with Estrogen Receptor-Positive Advanced Breast Cancer from Brazil. Journal of Oncology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1183993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reinert, Tomás…[et al.]. Association of ESR1 Mutations and Visceral Metastasis in Patients with Estrogen Receptor-Positive Advanced Breast Cancer from Brazil. Journal of Oncology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1183993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reinert, Tomás& Coelho, Guilherme Portela& Mandelli, Jovana& Zimermann, Edinéia& Zaffaroni, Facundo& Bines, José…[et al.]. Association of ESR1 Mutations and Visceral Metastasis in Patients with Estrogen Receptor-Positive Advanced Breast Cancer from Brazil. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1183993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر