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Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1p-STAT3 Signaling in Human Breast Cancers
المؤلفون المشاركون
Chiu, Yi-Han
Lee, Yi-Yen
Huang, Kuo-Chin
Liu, Cheng-Chi
Lin, Chen-Si
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Breast cancer is the most common cancer and the leading cause of cancer deaths in women worldwide.
The rising incidence rate and female mortality make it a significant public health concern in recent years.
Dovitinib is a novel multitarget receptor tyrosine kinase inhibitor, which has been enrolled in several clinical trials in different cancers.
However, its antitumor efficacy has not been well determined in breast cancers.
Our results demonstrated that dovitinib showed significant antitumor activity in human breast cancer cell lines with dose- and time-dependent manners.
Downregulation of phosphor-(p)-STAT3 and its subsequent effectors Mcl-1 and cyclin D1 was responsible for this drug effect.
Ectopic expression of STAT3 rescued the breast cancer cells from cell apoptosis induced by dovitinib.
Moreover, SHP-1 inhibitor reversed the downregulation of p-STAT3 induced by dovitinib, indicating that SHP-1 mediated the STAT3 inhibition effect of dovitinib.
In addition to apoptosis, we found for the first time that dovitinib also activated autophagy to promote cell death in breast cancer cells.
In conclusion, dovitinib induced both apoptosis and autophagy to block the growth of breast cancer cells by regulating the SHP-1-dependent STAT3 inhibition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chiu, Yi-Han& Lee, Yi-Yen& Huang, Kuo-Chin& Liu, Cheng-Chi& Lin, Chen-Si. 2019. Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1p-STAT3 Signaling in Human Breast Cancers. Journal of Oncology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184001
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chiu, Yi-Han…[et al.]. Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1p-STAT3 Signaling in Human Breast Cancers. Journal of Oncology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1184001
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chiu, Yi-Han& Lee, Yi-Yen& Huang, Kuo-Chin& Liu, Cheng-Chi& Lin, Chen-Si. Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1p-STAT3 Signaling in Human Breast Cancers. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184001
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184001
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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