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Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia
المؤلفون المشاركون
Matsuura, Kenji
Otani, Mieko
Takano, Masaoki
Kadoyama, Keiichi
Matsuyama, Shogo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aim.
Diabetes with its associated hyperglycemia induces various type of peripheral damage and also impairs the central nervous system (CNS).
This study is aimed at clarifying the precise mechanism of diabetes-induced dementia as an impairment of CNS.
Methods.
The proteomic analysis of the hippocampus and cortex in streptozotocin- (STZ-) treated mouse diabetic model showing dementia was performed using two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (n=3/group).
Results.
Significant changes in the expression of 32 proteins and 7 phosphoproteins were observed in the hippocampus and cortex.
These identified proteins and phosphoproteins could be functionally classified as cytoskeletal protein, oxidoreductase, protein deubiquitination, energy metabolism, GTPase activation, heme binding, hydrolase, iron storage, neurotransmitter release, protease inhibitor, transcription, glycolysis, antiapoptosis, calcium ion binding, heme metabolic process, protein degradation, vesicular transport, and unknown in the hippocampus or cortex.
Additionally, Western blotting validated the changes in translationally controlled tumor protein, ATP-specific succinyl-CoA synthetase beta subunit, and gamma-enolase isoform 1.
Conclusions.
These findings showed that STZ-induced diabetes changed the expression of proteins and phosphoproteins in the hippocampus and cortex.
We propose that alterations in expression levels of these proteins play an important role in diabetes-induced dementia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matsuura, Kenji& Otani, Mieko& Takano, Masaoki& Kadoyama, Keiichi& Matsuyama, Shogo. 2018. Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1184003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matsuura, Kenji…[et al.]. Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1184003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matsuura, Kenji& Otani, Mieko& Takano, Masaoki& Kadoyama, Keiichi& Matsuyama, Shogo. Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1184003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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