Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Discriminating Precancerous Pathologies from Cervical Cancer
المؤلفون المشاركون
Tas, Mustafa
Yavuz, Adem
Ak, Mehmet
Ozcelik, Bulent
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-29
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
We aimed to determine the predictive value of several hematological markers of inflammation on the presence/absence of cervical cancer and also to determine their ability in discriminating precancerous cervical pathologies from cervical cancer.
Materials and Methods.
In this study, patients who presented to Acıbadem Kayseri Hospital between May 2010 and June 2018 were evaluated.
Forty patients with low-grade squamous intraepithelial lesions (LSIL), 40 patients with high-grade squamous intraepithelial lesions (HSIL), and 30 patients with cervical cancer (CC) were retrospectively included in this study.
A control group of 70 healthy volunteers with normal cervical cytology was also included in the study.
Results.
The neutrophil-to-lymphocyte ratio (NLR) was significantly higher in patients with CC than in controls.
The platelet-to-lymphocyte ratio (PLR) was significantly higher in patients with CC compared to those with LSIL and HSIL diagnoses and also controls (p<0.001).
Logistic regression analysis revealed that age (OR: 1.075, 95% CI: 1.020–1.132, p=0.007), NLR (OR: 1.643, 95% CI: 1.009–3.142, p=0.047), and PLR (OR: 1.032, 95% CI: 1.003–1.062, p=0.029) were predictors for the presence of CC.
ROC curve analysis revealed that both NLR and PLR were predictive of CC with a cutoff value of 2.02 for NLR (71% sensitivity and 60% specificity, AUC: 0.682, p=0.004) and 126.7 for PLR (83% sensitivity and 69% specificity, AUC: 0.752, p<0.001).
Conclusion.
In addition to patients’ age, determination of NLR and PLR values, which are simple, inexpensive, and readily available markers of systemic inflammation, may help in decision making precancerous pathologies of the cervix.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tas, Mustafa& Yavuz, Adem& Ak, Mehmet& Ozcelik, Bulent. 2019. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Discriminating Precancerous Pathologies from Cervical Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1184049
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tas, Mustafa…[et al.]. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Discriminating Precancerous Pathologies from Cervical Cancer. Journal of Oncology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1184049
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tas, Mustafa& Yavuz, Adem& Ak, Mehmet& Ozcelik, Bulent. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Discriminating Precancerous Pathologies from Cervical Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1184049
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184049
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر