Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK
المؤلفون المشاركون
Takahashi, Kazuto
Morita, Naru
Hosaka, Toshio
Kitahara, Atsuko
Murashima, Toshitaka
Onuma, Hirohisa
Sumitani, Yoshikazu
Tanaka, Toshiaki
Kondo, Takuma
Ishida, Hitoshi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
A growing body of evidence indicates that AMP-activated protein kinase (AMPK) contributes to not only energy metabolic homeostasis but also the inhibition of inflammatory responses.
However, the underlying mechanisms remain unclear.
To elucidate the role of AMPK, in this study, we observed the effects of AMPK activation on monocyte chemoattractant protein-1 (MCP-1) release in mature 3T3-L1 adipocytes.
Methods.
We observed signal transduction pathways regulating MCP-1, which increased in obese adipocytes, in an in vitro model of hypertrophied 3T3-L1 adipocytes preloaded with palmitate.
Results.
Palmitate-preloaded cells exhibited significant increase in MCP-1 release and triglyceride (TG) deposition.
Increased MCP-1 release and TG deposition were significantly decreased by an AMPK activator.
In addition, the AMPK activator not only markedly diminished MCP-1 secretion but also augmented phosphorylation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinase (ERK) 1/2.
In contrast, MCP-1 release suppression was abolished by the AMPK inhibitor compound C and the MEK inhibitor U0126.
Conclusions.
MCP-1 release from hypertrophied adipocytes is suppressed by AMPK activation through the NF-κB and ERK pathways.
These findings provide evidence that AMPK plays a crucial role in ameliorating obesity-induced inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morita, Naru& Hosaka, Toshio& Kitahara, Atsuko& Murashima, Toshitaka& Onuma, Hirohisa& Sumitani, Yoshikazu…[et al.]. 2018. Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1184072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morita, Naru…[et al.]. Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1184072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morita, Naru& Hosaka, Toshio& Kitahara, Atsuko& Murashima, Toshitaka& Onuma, Hirohisa& Sumitani, Yoshikazu…[et al.]. Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1184072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر