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Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study
المؤلفون المشاركون
Vigelsø, Andreas Hansen
Dela, Flemming
Helge, Jørn Wulff
Larsen, Steen
Dandanell, Sune
Prats, Clara
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
A prevalent side-effect of simvastatin is attenuated glucose homeostasis.
The underlying mechanism is unknown, but impaired lipid metabolism may provide the link.
The aim of this study was to investigate whether simvastatin-treated patients had a lower capacity to oxidize lipids and reduced expression of the major proteins regulating lipid uptake, synthesis, lipolysis, and storage in skeletal muscle than matched controls.
Materials and Methods.
Ten men were treated with simvastatin (HbA1c: 5.7 ± 0.1%), and 10 healthy men (HbA1c: 5.2 ± 0.1%) underwent an oral glucose tolerance test and a muscle biopsy was obtained.
Fat oxidation rates were measured at rest and during exercise.
Western blotting was used to assess protein content.
Results.
Patients treated with simvastatin had impaired glucose tolerance compared with control subjects, but fat oxidation at rest and during exercise was compatible.
Skeletal muscle protein content of CD36, lipoprotein lipase (LPL), and diacylglycerol acyltransferase (DGAT) 1 were lower, and DGAT 2 tended to be lower in patients treated with simvastatin.
Conclusions.
Patients treated with simvastatin had a reduced capacity to synthesize FA and diacylglycerol (DAG) into triacylglycerol in skeletal muscle compared to matched controls.
Decreased lipid synthesis capacity may lead to accumulation of lipotoxic intermediates (FA and DAG) and hence impair glucose tolerance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Larsen, Steen& Vigelsø, Andreas Hansen& Dandanell, Sune& Prats, Clara& Dela, Flemming& Helge, Jørn Wulff. 2018. Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1184078
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Larsen, Steen…[et al.]. Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study. Journal of Diabetes Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1184078
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Larsen, Steen& Vigelsø, Andreas Hansen& Dandanell, Sune& Prats, Clara& Dela, Flemming& Helge, Jørn Wulff. Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1184078
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184078
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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