Characterization of PCL and Chitosan Nanoparticles as Carriers of Enoxaparin and Its Antithrombotic Effect in Animal Models of Venous Thrombosis
المؤلفون المشاركون
Durán, Nelson
Prado, Lucas Bessa
Huber, Stephany Cares
Barnabé, Aline
Bassora, Fernanda Dutra Santiago
Paixão, Devanira Souza
Annichino-Bizzacchi, Joyce Maria
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study was based on the preparation, characterization, and animal in vivo experiments performed to evaluate nanoparticles of poly(ɛ-caprolactone) (PCL) and chitosan as carriers of enoxaparin.
The nanoparticles were characterized and presented satisfactory results in terms of size, polydispersity, and encapsulation efficiency.
Anticoagulant activity of the nanoparticles was maintained for 14 hours when the administration was subcutaneous; however no activity was observed after oral administration.
There was a significant reduction in thrombus size, in vivo, for both free and encapsulated enoxaparin in comparison with the control group after subcutaneous administration.
Oral administration results however were indifferent.
In conclusion, the double emulsion method w/o/w was efficient for enoxaparin encapsulation, producing spherical nanoparticles with high encapsulation efficiency.
For in vivo studies, the encapsulated enoxaparin showed a sustained anticoagulant activity for a higher period of time compared to free enoxaparin, with an antithrombotic effect when administered subcutaneously.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prado, Lucas Bessa& Huber, Stephany Cares& Barnabé, Aline& Bassora, Fernanda Dutra Santiago& Paixão, Devanira Souza& Durán, Nelson…[et al.]. 2017. Characterization of PCL and Chitosan Nanoparticles as Carriers of Enoxaparin and Its Antithrombotic Effect in Animal Models of Venous Thrombosis. Journal of Nanotechnology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1184098
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prado, Lucas Bessa…[et al.]. Characterization of PCL and Chitosan Nanoparticles as Carriers of Enoxaparin and Its Antithrombotic Effect in Animal Models of Venous Thrombosis. Journal of Nanotechnology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1184098
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prado, Lucas Bessa& Huber, Stephany Cares& Barnabé, Aline& Bassora, Fernanda Dutra Santiago& Paixão, Devanira Souza& Durán, Nelson…[et al.]. Characterization of PCL and Chitosan Nanoparticles as Carriers of Enoxaparin and Its Antithrombotic Effect in Animal Models of Venous Thrombosis. Journal of Nanotechnology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1184098
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184098
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر