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Bioinformatic Analysis Reveals an ImmuneInflammatory-Related Risk Signature for Oral Cavity Squamous Cell Carcinoma
المؤلفون المشاركون
Bai, Shuang
Yan, Ying-Bin
Chen, Wei
Zhang, Ping
Zhang, Tong-Mei
Tian, Yuan-Yuan
Liu, Hao
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
High-throughput gene expression profiling has recently emerged as a promising technique that provides insight into cancer subtype classification and improved prediction of prognoses.
Immune/inflammatory-related mRNAs may potentially enrich genes to allow researchers to better illustrate cancer microenvironments.
Oral cavity squamous cell carcinoma (OC-SCC) exhibits high morbidity and poor prognosis compared to that of other types of head and neck squamous cell carcinoma (HNSCC), and these differences may be partially due to differences within the tumor microenvironments.
Based on this, we designed an immune-related signature to improve the prognostic prediction of OC-SCC.
A cohort of 314 OC-SCC samples possessing whole genome expression data that were sourced from The Cancer Genome Atlas (TCGA) database was included for discovery.
The GSE41613 database was used for validation.
A risk score was established using immune/inflammatory signatures acquired from the training dataset.
Principal components analysis, GO analysis, and gene set enrichment analysis were used to explore the bioinformatic implications.
When grouped by the dichotomized risk score based on the signature, this classifier could successfully discriminate patients with distinct prognoses within the training and validation cohorts (P<0.05 in both cohorts) and within different clinicopathological subgroups.
Similar somatic mutation patterns were observed between high and low risk score groups, and different copy number variation patterns were also identified.
Further bioinformatic analyses suggested that the lower risk score group was significantly correlated with immune/inflammatory-related biological processes, while the higher risk score group was highly associated with cell cycle-related processes.
The analysis indicated that the risk score was a robust predictor of patient survival, and its functional annotation was well established.
Therefore, this bioinformatic-based immune-related signature suggested that the microenvironment of OC-SCC could distinguish among patients with different underlying biological processes and clinical outcomes, and the use of this signature may shed light on future OC-SCC classification and therapeutic design.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bai, Shuang& Yan, Ying-Bin& Chen, Wei& Zhang, Ping& Zhang, Tong-Mei& Tian, Yuan-Yuan…[et al.]. 2019. Bioinformatic Analysis Reveals an ImmuneInflammatory-Related Risk Signature for Oral Cavity Squamous Cell Carcinoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bai, Shuang…[et al.]. Bioinformatic Analysis Reveals an ImmuneInflammatory-Related Risk Signature for Oral Cavity Squamous Cell Carcinoma. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bai, Shuang& Yan, Ying-Bin& Chen, Wei& Zhang, Ping& Zhang, Tong-Mei& Tian, Yuan-Yuan…[et al.]. Bioinformatic Analysis Reveals an ImmuneInflammatory-Related Risk Signature for Oral Cavity Squamous Cell Carcinoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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