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A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements
المؤلفون المشاركون
Ellsworth, Darrell L.
Turner, Clesson E.
Ellsworth, Rachel E.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Triple negative breast cancer (TNBC), representing 10-15% of breast tumors diagnosed each year, is a clinically defined subtype of breast cancer associated with poor prognosis.
The higher incidence of TNBC in certain populations such as young women and/or women of African ancestry and a unique pathological phenotype shared between TNBC and BRCA1-deficient tumors suggest that TNBC may be inherited through germline mutations.
In this article, we describe genes and genetic elements, beyond BRCA1 and BRCA2, which have been associated with increased risk of TNBC.
Multigene panel testing has identified high- and moderate-penetrance cancer predisposition genes associated with increased risk for TNBC.
Development of large-scale genome-wide SNP assays coupled with genome-wide association studies (GWAS) has led to the discovery of low-penetrance TNBC-associated loci.
Next-generation sequencing has identified variants in noncoding RNAs, viral integration sites, and genes in underexplored regions of the human genome that may contribute to the genetic underpinnings of TNBC.
Advances in our understanding of the genetics of TNBC are driving improvements in risk assessment and patient management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ellsworth, Darrell L.& Turner, Clesson E.& Ellsworth, Rachel E.. 2019. A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ellsworth, Darrell L.…[et al.]. A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ellsworth, Darrell L.& Turner, Clesson E.& Ellsworth, Rachel E.. A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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