Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches
المؤلفون المشاركون
McArt, Darragh G.
Ellis, H. P.
McInerney, C. E.
Schrimpf, D.
Sahm, F.
Stupnikov, A.
Wadsley, M.
Wragg, C.
White, P.
Prise, K. M.
Kurian, K. M.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Glioblastoma is the most common primary adult brain tumour, and despite optimal treatment, the median survival is 12–15 months.
Patients with matched recurrent glioblastomas were investigated to try to find actionable mutations.
Tumours were profiled using a validated DNA-based gene panel.
Copy number variations (CNVs) and single nucleotide variants (SNVs) were examined, and potentially pathogenic variants and clinically actionable mutations were identified.
The results revealed that glioblastomas were IDH-wildtype (IDHWT; n = 38) and IDH-mutant (IDHMUT; n = 3).
SNVs in TSC2, MSH6, TP53, CREBBP, and IDH1 were variants of unknown significance (VUS) that were predicted to be pathogenic in both subtypes.
IDHWT tumours had SNVs that impacted RTK/Ras/PI(3)K, p53, WNT, SHH, NOTCH, Rb, and G-protein pathways.
Many tumours had BRCA1/2 (18%) variants, including confirmed somatic mutations in haemangioblastoma.
IDHWT recurrent tumours had fewer pathways impacted (RTK/Ras/PI(3)K, p53, WNT, and G-protein) and CNV gains (BRCA2, GNAS, and EGFR) and losses (TERT and SMARCA4).
IDHMUT tumours had SNVs that impacted RTK/Ras/PI(3)K, p53, and WNT pathways.
VUS in KLK1 was possibly pathogenic in IDHMUT.
Recurrent tumours also had fewer pathways (p53, WNT, and G-protein) impacted by genetic alterations.
Public datasets (TCGA and GDC) confirmed the clinical significance of findings in both subtypes.
Overall in this cohort, potentially actionable variation was most often identified in EGFR, PTEN, BRCA1/2, and ATM.
This study underlines the need for detailed molecular profiling to identify individual GBM patients who may be eligible for novel treatment approaches.
This information is also crucial for patient recruitment to clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ellis, H. P.& McInerney, C. E.& Schrimpf, D.& Sahm, F.& Stupnikov, A.& Wadsley, M.…[et al.]. 2019. Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches. Journal of Oncology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ellis, H. P.…[et al.]. Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches. Journal of Oncology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1184256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ellis, H. P.& McInerney, C. E.& Schrimpf, D.& Sahm, F.& Stupnikov, A.& Wadsley, M.…[et al.]. Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر