![](/images/graphics-bg.png)
FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population
المؤلفون المشاركون
Oyeyemi, Bolaji Fatai
Ologunde, Charles Ayorinde
Olaoye, Ayonposi Bukola
Alamukii, Nanfizat Abiket
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect.
However, this is poorly understood in Nigeria due to scarce studies.
We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria.
FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls.
Anthropometrics and environmental variables were measured using standard procedures.
Significant associations were found between FTO rs9939609 with obesity and environmental/lifestyle variables before and after adjusting for age.
Carriers of allele A have significantly higher odds of being overweight/obese using BMI [0.191 (0.102–0.361), p<0.001] but this was attenuated by PA (p[interaction]=0.029); odds of being overweight reduced from 0.625 (0.181–2.159) to 0.082 (0.009–0.736) for low and high PA, respectively.
Mediation analysis of total indirect effect also confirmed this by showing a simultaneous mediating role of total PA, energy intake, and TSS in the relationship between FTO and BMI (unstandardized-coefficient = 1.68; 95% CI: 1.26–2.22).
This study shows a relationship between FTO and obesity phenotype and environmental/lifestyle factors might be an important modulator/mediator in the association.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oyeyemi, Bolaji Fatai& Ologunde, Charles Ayorinde& Olaoye, Ayonposi Bukola& Alamukii, Nanfizat Abiket. 2017. FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population. Journal of Obesity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1184271
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oyeyemi, Bolaji Fatai…[et al.]. FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population. Journal of Obesity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1184271
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oyeyemi, Bolaji Fatai& Ologunde, Charles Ayorinde& Olaoye, Ayonposi Bukola& Alamukii, Nanfizat Abiket. FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population. Journal of Obesity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1184271
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184271
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)