![](/images/graphics-bg.png)
Maintenance Therapy with FOLFIRI after FOLFIRINOX for Advanced Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Analysis
المؤلفون المشاركون
Canbay, Ali
Franck, Caspar
Venerito, Marino
Malfertheiner, Peter
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
Patients with pancreatic ductal adenocarcinoma (PDA) receiving FOLFIRINOX often develop oxaliplatin-induced polyneuropathy, which limits the continuation of this therapy.
We evaluated the efficacy and safety of FOLFIRI maintenance treatment after FOLFIRINOX induction in a retrospective single-center study.
Methods.
Patients with advanced PDA treated with FOLFIRI as maintenance therapy after achieving disease control under FOLFIRINOX according to the local operating procedure between 2011 and 2016 were identified.
Medical records of this group were evaluated retrospectively.
Results.
Overall, 22 patients with PDA were treated with FOLFIRI (mean age 59 years, 55% female, 45% male).
Before receiving FOLFIRI, all patients were treated with FOLFIRINOX for a median of 4 months.
The median progression-free survival (PFS) under FOLFIRI maintenance therapy was 8 months.
Side effects grade 3-4 (CTCAE v4.0) were observed in 18% of patients receiving FOLFIRI.
Considering together FOLFIRINOX induction and subsequent FOLFIRI maintenance therapy, the median PFS was 11 months.
The median overall survival (OS) from the beginning of palliative treatment was estimated at 46 months.
Conclusions.
In the selected group of PDA patients achieving disease control with FOLFIRINOX, FOLFIRI maintenance therapy was feasible, safe, and effective, with some patients achieving long-term disease stabilization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franck, Caspar& Canbay, Ali& Malfertheiner, Peter& Venerito, Marino. 2019. Maintenance Therapy with FOLFIRI after FOLFIRINOX for Advanced Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Analysis. Journal of Oncology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1184340
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franck, Caspar…[et al.]. Maintenance Therapy with FOLFIRI after FOLFIRINOX for Advanced Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Analysis. Journal of Oncology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1184340
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franck, Caspar& Canbay, Ali& Malfertheiner, Peter& Venerito, Marino. Maintenance Therapy with FOLFIRI after FOLFIRINOX for Advanced Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Center Analysis. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1184340
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184340
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)