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Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution
المؤلفون المشاركون
Powell, Mark J.
Dufault, Suzanne M.
Henry, Jill E.
Allison, Anna C.
Cora, Renata
Benz, Christopher C.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Terminal duct lobular units (TDLUs) are the anatomic sites of breast cancer initiation, and breast tissue involution resulting in lower TDLU counts has been associated with decreased breast cancer risk.
The insulin-like growth factor (IGF) pathway plays a role in breast involution, and systemic changes in this developmental pathway occur with hypertensive disorders of pregnancy (HDP), which have also been associated with lower breast cancer risk, especially in women carrying a functional variant of IGF1R SNP rs2016347.
We proposed that this breast cancer protective effect might be explained by increased breast tissue involution.
Materials and Methods.
We conducted a retrospective cohort study utilizing the Komen Tissue Bank, which collects breast tissue core biopsies from women without a history of breast cancer.
Eighty white non-Hispanic women with a history of HDP were selected along with 120 nonexposed participants, and after genotyping for rs2016347, TDLU parameters were histologically measured blinded to participant characteristics from fixed biopsy sections.
Results.
Stratified models by HDP status demonstrated that among HDP+ participants, those carrying two T alleles of rs2016347 had a decrease in TDLU counts of 53.2% when compared to those with no T alleles (p=0.049).
Trend analysis demonstrated a multiplicative decrease in counts of 31.6% per T allele (p=0.050).
Although no statistically significant interaction was seen between HDP status and T alleles, interaction terms showed increasingly negative values reaching a p value of 0.124 for HDP × 2T alleles.
Conclusions.
The observed statistically significant decrease in TDLU counts signifies increased breast epithelial involution in women with prior HDP who inherited the TT genotype of IGF1R SNP rs2016347.
The increasing degree of breast involution with greater rs2016347 T allele copy number is consistent with the known progressive reduction in IGF1R expression in breast and other normal tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Powell, Mark J.& Dufault, Suzanne M.& Henry, Jill E.& Allison, Anna C.& Cora, Renata& Benz, Christopher C.. 2019. Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Powell, Mark J.…[et al.]. Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1184380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Powell, Mark J.& Dufault, Suzanne M.& Henry, Jill E.& Allison, Anna C.& Cora, Renata& Benz, Christopher C.. Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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