Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma
المؤلفون المشاركون
Sigala, Sandra
Fiorentini, Chiara
Grisanti, Salvatore
Cosentini, Deborah
Abate, Andrea
Rossini, Elisa
Berruti, Alfredo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer, often insensitive to conventional chemotherapeutics agents.
Early diagnosis, followed by radical surgical resection plus/minus adjuvant mitotane therapy, is nowadays the only valuable option.
Unfortunately, one out of four patients has metastatic disease at diagnosis and most of radically resected ACC patients are destined to recur with local or metastatic disease.
Numerous efforts aimed at identifying molecular alterations crucial for ACC pathogenesis have been extensively conducted, with the hope to develop new treatments.
Indeed, multiple genes and pathways have been identified as potentially targetable in ACC patients; however, despite the strong preclinical rationale, translational findings to clinical trials led to date to disappointing results.
The immunotherapeutic intervention targeting T-cell checkpoint molecules has been proposed as well, but results obtained in early studies indicate that ACC patients would be unlikely to benefit from immunotherapy.
Genetic alterations of different pathways involved in ACC carcinogenesis are also known substrates of resistance to immunotherapy.
Among them, β-catenin gene CTNNB1 and TP53 gene are frequently mutated in ACC samples.
Overactivation of the β-catenin pathway and loss of p53 protein function are potential tumor-intrinsic factors that, impacting on the ability of ACC cells to recruit dendritic cells, leading to T-cell exclusion, put this tumor among those that are potentially resistant to immunotherapy.
Moreover, the steroid phenotype, which implies glucocorticoids hypersecretion in a subset of ACC, contributes to generating an immunosuppressive microenvironment.
Here, we review clinical results of immunotherapy in ACC and we highlight molecular mechanisms driving immunotherapy failure in ACC, suggesting possible approaches to overcome resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fiorentini, Chiara& Grisanti, Salvatore& Cosentini, Deborah& Abate, Andrea& Rossini, Elisa& Berruti, Alfredo…[et al.]. 2019. Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fiorentini, Chiara…[et al.]. Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma. Journal of Oncology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1184385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fiorentini, Chiara& Grisanti, Salvatore& Cosentini, Deborah& Abate, Andrea& Rossini, Elisa& Berruti, Alfredo…[et al.]. Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر