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Role of Cancer-Associated Fibroblast in Gastric Cancer Progression and Resistance to Treatments
المؤلفون المشاركون
Hur, Hoon
Ham, In-Hye
Lee, Dagyeong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Although the survival of gastric cancer (GC) patients has gradually improved, the outcomes of advanced GC patients remain unsatisfactory despite standard treatment with conventional chemotherapy or targeted agents.
Several studies have shown that cancer-associated fibroblasts (CAFs), a major component of tumor stroma in GC, may have significant roles in GC progression and resistance to treatments.
CAFs are a major source of various secreted molecules in the tumor microenvironment, which stimulate cancer cells and other noncancerous components of GC.
Surprisingly, these factors could be involved in gastric carcinogenesis.
Cytokines, including interleukin-6 and interleukin-11, or growth factors, such as fibroblast growth factor produced from CAFs, can directly activate GC cells and consequently lead to the development of an aggressive phenotype.
Galectin-1 or hepatocyte growth factor can be involved in CAF-derived neovascularization in GC.
In addition, recent studies showed that CAFs can affect tumor immunity through M2 polarization of tumor-associated macrophages.
Finally, the current study aimed to introduce several inhibitory agents and evaluate their suppressive effects on CAFs in patients with GC progression.
However, further studies are required to evaluate their safety and select appropriate patients for application in clinical settings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ham, In-Hye& Lee, Dagyeong& Hur, Hoon. 2019. Role of Cancer-Associated Fibroblast in Gastric Cancer Progression and Resistance to Treatments. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ham, In-Hye…[et al.]. Role of Cancer-Associated Fibroblast in Gastric Cancer Progression and Resistance to Treatments. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ham, In-Hye& Lee, Dagyeong& Hur, Hoon. Role of Cancer-Associated Fibroblast in Gastric Cancer Progression and Resistance to Treatments. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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