TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study
المؤلفون المشاركون
Alanazi, Mohammed
Aljebreen, Abdulrahman M.
Alharbi, Othman
Alanazi, Ibrahim O.
Aldhaian, Sooad
Almadi, Majid A.
Azzam, Nahla A.
Purusottapatnam Shaik, Jilani
Reddy Parine, Narasimha
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Genetic alterations that might lead to colorectal cancer involve essential genes including those involved in DNA repair, inclusive of base excision repair (BER).
Thymine DNA glycosylase (TDG) is one of the most well characterized BER genes that catalyzes the removal of thymine moieties from G/T mismatches and is also involved in many cellular functions, such as the regulation of gene expression, transcriptional coactivation, and the control of epigenetic DNA modification.
Mutation of the TDG gene is implicated in carcinogenesis.
In the present study, we aimed to investigate the association between TDG gene polymorphisms and their involvement in colon cancer susceptibility.
One hundred blood samples were obtained from colorectal cancer patients and healthy controls for the genotyping of seven SNPs in the TDG gene.
DNA was extracted from the blood, and the polymorphic sites (SNPs) rs4135113, rs4135050, rs4135066, rs3751209, rs1866074, and rs1882018 were investigated using TaqMan genotyping.
One of the six TDG SNPs was associated with an increased risk of colon cancer.
The AA genotype of the TDG SNP rs4135113 increased the risk of colon cancer development by more than 3.6-fold, whereas the minor allele A increased the risk by 1.6-fold.
It also showed a 5-fold higher risk in patients over the age of 57.
SNP rs1866074 showed a significant protective association in CRC patients.
The GA genotype of TDG rs3751209 was associated with a decreased risk in males.
There is a significant relationship between TDG gene function and colorectal cancer progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reddy Parine, Narasimha& Alanazi, Ibrahim O.& Purusottapatnam Shaik, Jilani& Aldhaian, Sooad& Aljebreen, Abdulrahman M.& Alharbi, Othman…[et al.]. 2019. TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reddy Parine, Narasimha…[et al.]. TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1184475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reddy Parine, Narasimha& Alanazi, Ibrahim O.& Purusottapatnam Shaik, Jilani& Aldhaian, Sooad& Aljebreen, Abdulrahman M.& Alharbi, Othman…[et al.]. TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر