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Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma
المؤلفون المشاركون
Ren, Ming
Yang, Qiwei
Wang, Qingyu
Chen, Gaoyang
Li, Zhaoyan
Sun, Hongyan
Yang, Jinghui
Cong, Xianling
Liu, Tao
Yu, Shan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-24
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide.
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor.
Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear.
In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis.
An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs.
Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network.
The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line.
A total of 278 circRNAs were identified as differentially expressed in PDAC tissue.
Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC.
In vitro experiments confirmed these results.
The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Jinghui& Cong, Xianling& Ren, Ming& Sun, Hongyan& Liu, Tao& Chen, Gaoyang…[et al.]. 2019. Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1184538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Jinghui…[et al.]. Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma. Journal of Oncology No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1184538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Jinghui& Cong, Xianling& Ren, Ming& Sun, Hongyan& Liu, Tao& Chen, Gaoyang…[et al.]. Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1184538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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