Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease
المؤلفون المشاركون
Tsubota, Kazuo
Kawakami, Yutaka
Fukui, Masaki
Ogawa, Yoko
Mukai, Shin
Kamoi, Mizuka
Asato, Teru
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate whether the SNARE protein vesicle-associated membrane protein 8 (VAMP8) was implicated in the development of chronic ocular graft-versus-host disease (GVHD).
Methods.
Firstly, the chronic GVHD (cGVHD) and Sjögren’s syndrome (SS)-impaired lacrimal gland (LG) tissue sections from humans for diagnostic purpose were evaluated for VAMP8 expression by histopathology and immunohistochemistry.
Next, serial changes of tear secretion and VAMP8 expression at both protein and mRNA level of LG in an animal cGVHD model compared with the syngeneic control.
Results.
Decreased VAMP 8 expression in the cGVHD-affected human LG was detected in comparison with SS-affected LG.
Tear secretion in the murine cGVHD model was significantly reduced compared with that in the syngeneic controls 8 weeks after BMT.
Protein expression of VAMP8 in the cGVHD-affected LG in murine cGVHD was decreased in comparison with that in the controls.
Gene expression of VAMP8 in the cGVHD-affected murine LG was significantly less than that in the syngeneic control 3 weeks after BMT.
Conclusions.
Our results suggested that expression of VAMP8 in the cGVHD-affected LG was decreased and accordingly tear secretion in cGVHD was reduced.
Collectively, the reduction of VAMP8 expression in the cGVHD-affected LG can be involved in the pathogenic processes of cGVHD-induced dry eye disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fukui, Masaki& Ogawa, Yoko& Mukai, Shin& Kamoi, Mizuka& Asato, Teru& Kawakami, Yutaka…[et al.]. 2017. Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1184540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fukui, Masaki…[et al.]. Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease. Journal of Ophthalmology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1184540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fukui, Masaki& Ogawa, Yoko& Mukai, Shin& Kamoi, Mizuka& Asato, Teru& Kawakami, Yutaka…[et al.]. Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1184540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر