Accelerated Hyperfractionated Radiotherapy versus Conventional Fractionation Radiotherapy for Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Jiang, Xin
Kou, Changgui
Zhu, Bo
Bai, Wei
Yu, Weiying
Zhang, Lili
Yu, Xiao
Xu, Wen
Wang, Huanhuan
Xin, Ying
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The benefits of accelerated hyperfractionated radiotherapy (HART) and conventional fractionation radiotherapy (CFRT) in the treatment of head and neck cancer (HNC) remain controversial.
In this study, we analyzed the therapeutic effects of these two treatment regimens to explore whether HART can improve the overall survival (OS) rate and locoregional control (LRC) rate in patients with HNC.
Methods.
The PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for eligible studies.
The OS rate and LRC rate were considered as the efficacy outcomes.
I2 was used to test the heterogeneity among studies with a cutoff value of 50%.
Potential publication bias was assessed by funnel plots and Egger’s test.
We also performed a sensitivity analysis to assess the stability of the results.
In this meta-analysis, all analyses were performed using R 3.5.3 software.
Results.
Twelve qualified articles including a total of 2,935 patients were identified.
HART had a significant beneficial effect on OS rate (HR = 0.80, 95% CI: 0.65–0.98).
Compared with CFRT, HART demonstrated a significantly higher LRC rate (HR = 0.82, 95% CI: 0.71–0.96).
Conclusion.
Our meta-analysis showed that HART can significantly improve OS and LRC compared with CFRT in patients with HNC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Bo& Kou, Changgui& Bai, Wei& Yu, Weiying& Zhang, Lili& Yu, Xiao…[et al.]. 2019. Accelerated Hyperfractionated Radiotherapy versus Conventional Fractionation Radiotherapy for Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184542
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Bo…[et al.]. Accelerated Hyperfractionated Radiotherapy versus Conventional Fractionation Radiotherapy for Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1184542
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Bo& Kou, Changgui& Bai, Wei& Yu, Weiying& Zhang, Lili& Yu, Xiao…[et al.]. Accelerated Hyperfractionated Radiotherapy versus Conventional Fractionation Radiotherapy for Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184542
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184542
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر