MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels
المؤلفون المشاركون
Ortiz, Carmen
Matta, Jaime
Encarnación-Medina, Jarline
Vergne, Ralphdy
Padilla, Luis
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide and is the leading cause of death among Hispanic women.
Previous studies have shown that women with a low DNA repair capacity (DRC), measured through the nucleotide excision repair (NER) pathway, have an increased BC risk.
Moreover, we previously reported an association between DRC levels and the expression of the microRNA (miRNA) let-7b in BC patients.
MiRNAs can induce genomic instability by affecting the cell’s DNA damage response while influencing the cancer pathobiology.
The aim of this pilot study is to identify plasma miRNAs related to variations in DRC levels in BC cases.
Hypothesis.
Our hypothesis consists in testing whether DRC levels can be correlated with miRNA expression levels.
Methods.
Plasma samples were selected from 56 (27 cases and 29 controls) women recruited as part of our BC cohort.
DRC values were measured in lymphocytes using the host-cell reactivation assay.
The samples were divided into two categories: low (≤3.8%) and high (>3.8%) DRC levels.
MiRNAs were extracted to perform an expression profile analysis.
Results.
Forty miRNAs were identified to be BC-related (p<0.05, MW), while 18 miRNAs were found to be differentially expressed among BC cases and controls with high and low DRC levels (p<0.05, KW).
Among these candidates are miR-299-5p, miR-29b-3p, miR-302c-3p, miR-373-3p, miR-636, miR-331-5p, and miR-597-5p.
Correlation analyses revealed that 4 miRNAs were negatively correlated within BC cases with low DRC (p<0.05, Spearman’s correlation).
Results from multivariate analyses revealed that the clinicopathological characteristics may not have a direct effect on specific miRNA expression.
Conclusion.
This pilot study provides evidence of four miRNAs that are negatively regulated in BC cases with low DRC levels.
Additional studies are needed in order to have a complete framework regarding the overall DRC levels, miRNA expression profiles, and tumor characteristics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Encarnación-Medina, Jarline& Ortiz, Carmen& Vergne, Ralphdy& Padilla, Luis& Matta, Jaime. 2019. MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels. Journal of Oncology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184543
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Encarnación-Medina, Jarline…[et al.]. MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels. Journal of Oncology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1184543
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Encarnación-Medina, Jarline& Ortiz, Carmen& Vergne, Ralphdy& Padilla, Luis& Matta, Jaime. MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184543
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184543
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر