![](/images/graphics-bg.png)
Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems
المؤلفون المشاركون
Jonckx, Bart
Porcu, Michael
Candi, Aurelie
Etienne, Isabelle
Barbeaux, Philippe
Feyen, Jean H. M.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Ocriplasmin (Jetrea®) is a recombinant protease used to treat vitreomacular traction.
To gain insight into vitreoretinal observations reported after ocriplasmin treatment, we have developed an in vivo porcine ocriplasmin-induced posterior vitreous detachment (PVD) model in which we investigated vitreoretinal tissues by optical coherence tomography, histology, and cytokine profiling.
Eight weeks postinjection, ocriplasmin yielded PVD in 82% of eyes.
Subretinal fluid (85%) and vitreous hyperreflective spots (45%) were resolved by week 3.
Histological analysis of extracellular matrix (ECM) proteins such as laminin, fibronectin, and collagen IV indicated no retinal ocriplasmin-induced ECM distribution changes.
Retinal morphology was unaffected in all eyes.
Cytokine profiles of ocriplasmin-treated eyes were not different from vehicle.
In cell-based electrical resistance assays, blood-retinal barrier permeability was altered by ocriplasmin concentrations of 6 μg/mL and higher, with all effects being nontoxic, cell-type specific, and reversible.
Ocriplasmin was actively taken up by RPE and Müller cells, and our data suggest both lysosomal and transcellular clearance routes for ocriplasmin.
In conclusion, transient hyperreflective spots and fluid in a porcine ocriplasmin-induced PVD model did not correlate with retinal ECM rearrangement nor inflammation.
Reversible in vitro effects on blood-retinal barrier permeability provide grounds for a hypothesis on the mechanisms behind transient subretinal fluid observed in ocriplasmin-treated patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jonckx, Bart& Porcu, Michael& Candi, Aurelie& Etienne, Isabelle& Barbeaux, Philippe& Feyen, Jean H. M.. 2017. Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1184593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jonckx, Bart…[et al.]. Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems. Journal of Ophthalmology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1184593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jonckx, Bart& Porcu, Michael& Candi, Aurelie& Etienne, Isabelle& Barbeaux, Philippe& Feyen, Jean H. M.. Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1184593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)