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A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition
المؤلفون المشاركون
Bentivegna, Angela
Cadamuro, Massimiliano
Cilibrasi, Chiara
Guzzi, Andrèe
Bazzoni, Riccardo
Riva, Gabriele
Hochegger, Helfrid
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Glioma stem cells account for glioblastoma relapse and resistance to conventional therapies, and protein kinases, involved in the regulation of the mitotic machinery (i.e., Aurora kinases), have recently emerged as attractive therapeutic targets.
In this study, we investigated the effect of Aurora kinases inhibition in five glioma stem cell lines isolated from glioblastoma patients.
As expected, cell lines responded to the loss of Aurora kinases with cytokinesis failure and mitotic exit without cell division.
Surprisingly, this resulted in a proliferative arrest in only two of the five cell lines.
These sensitive cell lines entered a senescent/autophagic state following aberrant mitotic exit, while the non-sensitive cell lines continued to proliferate.
This senescence response did not correlate with TP53 mutation status but only occurred in the cell lines with the highest chromosome content.
Repeated rounds of Aurora kinases inhibition caused a gradual increase in chromosome content in the resistant cell lines and eventually caused a similar senescence response and proliferative arrest.
Our results suggest that a ploidy threshold is the main determinant of Aurora kinases sensitivity in TP53 mutant glioma stem cells.
Thus, ploidy could be used as a biomarker for treating glioma patients with Aurora kinases inhibitors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cilibrasi, Chiara& Guzzi, Andrèe& Bazzoni, Riccardo& Riva, Gabriele& Cadamuro, Massimiliano& Hochegger, Helfrid…[et al.]. 2019. A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. Journal of Oncology،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1184649
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cilibrasi, Chiara…[et al.]. A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. Journal of Oncology No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1184649
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cilibrasi, Chiara& Guzzi, Andrèe& Bazzoni, Riccardo& Riva, Gabriele& Cadamuro, Massimiliano& Hochegger, Helfrid…[et al.]. A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1184649
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184649
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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