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The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function
المؤلفون المشاركون
Wu, Tsung-Han
Yeh, Kun-Yun
Wang, Chen-Hsu
Wang, Hang
Chan, Yi-Lin
Wu, Chang-Jer
Li, Tsung-Lin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-03
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Lung cancer and its related cachexia are the leading cause of cancer death in the world.
In this study, we report the inhibitory effect of the combined therapy of Astragalus membranaceus and Angelica sinensis, on tumor growth and cachexia in tumor-bearing mice.
Lewis lung carcinoma cells were inoculated into male C57BL/6 and CAnN.Cg-Foxn1nu nude mice.
After tumor inoculation, mice were fed orally by the combination of AM and AS in different doses.
In C57BL/6 mice, the combination of AM and AS significantly inhibited the growth of cancer tumor and prevented the loss of body weight and skeletal muscle.
It also diminished the formation of free radicals and cytokines, stimulated the differentiation of NK and Tc cells, and rebalanced the ratios of Th/Tc cells, Th1/Th2 cytokines, and M1/M2 tumor-associated macrophages.
The herbal combination also downregulated the expression of NFκΒ, STAT3, HIF-1α, and VEGF in tumors.
In contrast, the findings were not observed in the nude mice.
Therefore, the combination of AM and AS is confirmed to inhibit the progression of lung cancer, cancer cachexia, and cancer inflammation through the immunomodulatory function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Tsung-Han& Yeh, Kun-Yun& Wang, Chen-Hsu& Wang, Hang& Li, Tsung-Lin& Chan, Yi-Lin…[et al.]. 2019. The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function. Journal of Oncology،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1184674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Tsung-Han…[et al.]. The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function. Journal of Oncology No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1184674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Tsung-Han& Yeh, Kun-Yun& Wang, Chen-Hsu& Wang, Hang& Li, Tsung-Lin& Chan, Yi-Lin…[et al.]. The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1184674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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