Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center
المؤلفون المشاركون
Chen, Ying-Tai
Wang, Cheng-Feng
Ren, Hu
Wang, Nian-Chang
Zhao, Dong-Bing
Zhao, Lulu
Huang, Huang
Tian, Yantao
Yuan, Xinghua
Ma, Fuhai
Zhao, Yajie
Aimaiti, Saderbiek
Zhang, Shuisheng
Zhou, Hong
Wang, Tongbo
Sun, Yuemin
Bai, Xiaofeng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
The prognostic relevance of gastric tumor location has been reported and debated.
Our study was conducted to examine the differences in clinicopathological features, prognostic factors, and overall survival (OS) between patients with proximal gastric cancer (PGC) and distal gastric cancer (DGC).
Patients and Methods.
Patients with PGC or DGC were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) during 1997–2017.
Survival analysis was performed via Kaplan-Meier estimates and Cox proportional hazards models.
Results.
We reviewed 16,119 cases of gastric cancer patients, including 6,479 of PGC and 9,640 of DGC.
PGC patients presented as older patients (61.5 versus 56.4 years, P<0.001) and more males (82.9% versus 68.2%, P<0.001).
Compared with DGC, PGC was more likely to be in later pT stage (pT3 and pT4, 65.0% versus 52.8%, P<0.001) and lymph node metastasis (54.8% versus 50.9%, P<0.001).
In univariate analysis, PGC patients had a worse survival outcome in stage I (Hazard ratio [HR] = 2.04, 95% CI: 1.42-2.94) but a better prognosis in stage IV (HR = 0.85, 95% CI: 0.73-0.98) when compared to DGC patients.
However, multivariate analysis demonstrated that PGC was not an independent predictor for poor survival (HR = 1.07, 95% CI: 1.00-1.14).
Results from multivariate analysis also revealed that pT4, lymph node metastasis, distant metastasis, no gastrectomy, and Borrmann IV were independent predictors associated with poor survival for both PGC and DGC patients.
Additional prognostic factors for PGC patients included underweight (BMI < 18.5) (HR = 1.29, 95% CI: 1.06-1.58), linitis plastica (HR = 2.13, 95% CI: 1.25-3.65), and overweight (23 ≤ BMI <27.5) (HR = 0.80, 95% CI: 0.71-0.90).
During the 20-year study period, the 5-year OS increased significantly for both PGC and DGC, with the increase rate of 91.7% and 67.7%, respectively.
Conclusion.
In China, PGC significantly differed from DGC in clinicopathological characteristics and prognostic factors.
However, there was no significant relationship between survival outcome and gastric tumor location.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Lulu& Huang, Huang& Zhao, Dong-Bing& Wang, Cheng-Feng& Tian, Yantao& Yuan, Xinghua…[et al.]. 2019. Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center. Journal of Oncology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1184752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Lulu…[et al.]. Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center. Journal of Oncology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1184752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Lulu& Huang, Huang& Zhao, Dong-Bing& Wang, Cheng-Feng& Tian, Yantao& Yuan, Xinghua…[et al.]. Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1184752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر