Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer
المؤلفون المشاركون
Cabanel, Mariana
Pereira, Jonathas Xavier
dos Santos, Sofia Nascimento
Pereira, Thaís Canuto
Chammas, Roger
de Oliveira, Felipe Leite
Bernardes, Emerson Soares
El-Cheikh, Márcia Cury
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-17
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Galectin-3 (Gal-3) is a multifunctional β-galactoside-binding lectin that once synthesized is expressed in the nucleus, cytoplasm, cell surface, and extracellular environment.
Gal-3 plays an important role in breast cancer tumors due to its ability to promote interactions between cell-cell and cell-extracellular matrix (ECM) elements, increasing tumor survival and metastatic dissemination.
Still, the mechanism by which Gal-3 interferes with tumor cell migration and metastasis formation is complex and not fully understood.
Here, we showed that Gal-3 knockdown increased the migration ability of 4T1 murine breast cancer cells in vitro.
Using the 4T1 orthotopic breast cancer spontaneous metastasis mouse model, we demonstrated that 4T1-derived tumors were significantly larger in the presence of Gal-3 (scramble) in comparison with Gal-3 knockdown 4T1-derived tumors.
Nevertheless, Gal-3 knockdown 4T1 cells were outnumbered in the bone marrow in comparison with scramble 4T1 cells.
Finally, we reported here a decrease in the content of cell-surface syndecan-1 and an increase in the levels of chondroitin sulfate proteoglycans such as versican in Gal-3 knockdown 4T1 cells both in vitro and in vivo.
Overall, our findings establish that Gal-3 downregulation during breast cancer progression regulates cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycans (PG), thus enhancing the metastatic potential of tumor cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pereira, Jonathas Xavier& dos Santos, Sofia Nascimento& Pereira, Thaís Canuto& Cabanel, Mariana& Chammas, Roger& de Oliveira, Felipe Leite…[et al.]. 2019. Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1184758
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pereira, Jonathas Xavier…[et al.]. Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer. Journal of Oncology No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1184758
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pereira, Jonathas Xavier& dos Santos, Sofia Nascimento& Pereira, Thaís Canuto& Cabanel, Mariana& Chammas, Roger& de Oliveira, Felipe Leite…[et al.]. Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1184758
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184758
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر