Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes
المؤلفون المشاركون
Wang, Shuaishuai
Wang, Zheng
Yang, Shuo
Yin, Tiemei
Zhang, Yaoli
Qin, Yuanjun
Sun, Xufang
Weinreb, Robert Neal
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
This study was performed to measure the concentration of trans-resveratrol and its three metabolites in human eyes.
Methods.
The patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment were included.
The participants were orally given trans-resveratrol-based supplement (Longevinex®).
A suitable amount of conjunctiva, aqueous humor, and vitreous humor were obtained during the operation.
High-performance liquid chromatography (HPLC) with mass spectrometry (LC/MS/MS) was used to detect the concentration of trans-resveratrol and its three metabolites in the various samples.
Results.
The average concentration of resveratrol in the conjunctiva was 17.19 ± 15.32 nmol/g (mean ± SD).
The concentration of resveratrol in the aqueous humor was close to the limit of detection, but its metabolites could be quantified.
The concentrations of resveratrol metabolites in the aqueous humor can be detected.
In the vitreous humor, the average concentration of resveratrol-3-O-sulfate was 62.95 ± 41.97 nmol/L.
The sulfate conjugations of resveratrol were recovered in the conjunctiva, aqueous humor, and vitreous humor.
Conclusions.
Resveratrol and its three metabolites can be detected in the ocular tissues after oral administration.
Although the concentration of parent resveratrol was low in the eyes, its metabolites could be detected and may have a role in the treatment of ocular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shuaishuai& Wang, Zheng& Yang, Shuo& Yin, Tiemei& Zhang, Yaoli& Qin, Yuanjun…[et al.]. 2017. Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1184875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shuaishuai…[et al.]. Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes. Journal of Ophthalmology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1184875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shuaishuai& Wang, Zheng& Yang, Shuo& Yin, Tiemei& Zhang, Yaoli& Qin, Yuanjun…[et al.]. Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1184875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر