Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects
المؤلفون المشاركون
Szentmáry, Nóra
Langenbucher, Achim
Wagenpfeil, Stefan
Flaskó, Zsuzsa
Zemova, Elena
Eppig, Timo
Módis, László
Seitz, Berthold
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To analyze the association between hypothyroidism and keratoconus, we examined blood thyroid hormone levels and corneal tomographic parameters in healthy subjects and patients with keratoconus.
Methods.
We included 626 subjects (304 left eyes, 49%; 431 males, 69%; age 38.4 ± 14.3 y).
Patients with keratoconus were from our Homburg Keratoconus Center (HKC) (n = 463); patients with hypothyroidism were from the Department of Internal Medicine of Saarland Medical University, Homburg/Saar, Germany (n = 75); and healthy subjects were from the Department of Ophthalmology of Saarland University Medical Center (n = 88).
We included only one randomly selected eye of each subject and the first examination data.
Exclusion criteria.
Previous thyroid medication, previous ocular surgery, and patients with suspected keratoconus (topographic keratoconus classification, [TKC]: 0 < 1).
Patient eyes were classified (TKC) with dedicated, instrument-based, keratoconus detection software provided with the Pentacam.
TKC = 0 was considered “normal,” and TKCs ≥ 1 were considered keratoconus.
Subjects were also classified as euthyroid or hypothyroid, based on blood thyroid hormone status (i.e., TSH, FT3, and FT4).
A multiple logistic linear regression model was constructed to determine the effects of age (covariate), gender, and hypothyroidism (effect sizes) on “TKC-positive” disease.
Results.
The significance levels for a constant parameter, sex, thyroid condition, and age were p<0.0001, p<0.0001, p<0.0001, and p=0.003, respectively.
The odds ratios for age, sex, and hypothyroidism were 0.98, 3.05, and 3.34, respectively.
Male sex and a euthyroid condition had significantly positive, clinically relevant effects, and age had a significantly negative, but clinically irrelevant effect on the estimated TKC index.
Conclusions.
Keratoconus appeared to occur more often in patients classified as euthyroid than in patients with hypothyroidism.
Thus, hypothyroidism alone could not support the development of keratoconus.
Based on these results, it should not be mandatory to screen patients with hypothyroidism for keratoconus or patients with keratoconus for hypothyroidism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Flaskó, Zsuzsa& Zemova, Elena& Eppig, Timo& Módis, László& Langenbucher, Achim& Wagenpfeil, Stefan…[et al.]. 2019. Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1185416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Flaskó, Zsuzsa…[et al.]. Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects. Journal of Ophthalmology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1185416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Flaskó, Zsuzsa& Zemova, Elena& Eppig, Timo& Módis, László& Langenbucher, Achim& Wagenpfeil, Stefan…[et al.]. Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1185416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1185416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر