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Rho-KinaseROCK as a Potential Drug Target for Vitreoretinal Diseases
المؤلفون المشاركون
Yamaguchi, Muneo
Arima, Mitsuru
Wada, Iori
Kaizu, Yoshihiro
Hao, Feng
Yoshida, Shigeo
Sonoda, Koh-hei
Nakao, Shintaro
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Rho-associated kinase (Rho-kinase/ROCK) was originally identified as an effector protein of the G protein Rho.
Its involvement in various diseases, particularly cancer and cardiovascular disease, has been elucidated, and ROCK inhibitors have already been applied clinically for cerebral vasospasm and glaucoma.
Vitreoretinal diseases including diabetic retinopathy, age-related macular degeneration, and proliferative vitreoretinoapthy are still a major cause of blindness.
While anti-VEGF therapy has recently been widely used for vitreoretinal disorders due to its efficacy, attention has been drawn to new unmet needs.
The importance of ROCK in pathological vitreoretinal conditions has also been elucidated and is attracting attention as a potential therapeutic target.
ROCK is involved in angiogenesis and hyperpermeability and also in the pathogenesis of various pathologies such as inflammation and fibrosis.
It has been expected that ROCK inhibitors will become new molecular target drugs for vitreoretinal diseases.
This review summarizes the recent progress on the mechanisms of action of ROCK and their applications in disease treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yamaguchi, Muneo& Nakao, Shintaro& Arima, Mitsuru& Wada, Iori& Kaizu, Yoshihiro& Hao, Feng…[et al.]. 2017. Rho-KinaseROCK as a Potential Drug Target for Vitreoretinal Diseases. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yamaguchi, Muneo…[et al.]. Rho-KinaseROCK as a Potential Drug Target for Vitreoretinal Diseases. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1185515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yamaguchi, Muneo& Nakao, Shintaro& Arima, Mitsuru& Wada, Iori& Kaizu, Yoshihiro& Hao, Feng…[et al.]. Rho-KinaseROCK as a Potential Drug Target for Vitreoretinal Diseases. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1185515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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