Outer Nuclear Layer as the Main Predictor to Anatomic Response to Half Dose Photodynamic Therapy in Chronic Central Serous Retinopathy
المؤلفون المشاركون
Falcão, Manuel
Sousa, Keissy
Viana, Ana Rita
Pires, Joana
Ferreira, Carla
Queirós, Lara
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the predictors for subretinal fluid resorption in patients with chronic central serous retinopathy (cCSR) submitted to half-dose photodynamic therapy (HD-PDT).
Methods.
Observational, longitudinal, and retrospective study of patients with cCSR submitted to HD-PDT in a tertiary ophthalmology department in Portugal between January 2015 and February 2018.
Best-corrected visual acuity (BCVA) and SD-OCT at baseline and 12 ± 3 months after treatment were performed.
The central macular thickness (CMT), outer nuclear layer (ONL) thickness, integrity of the external limiting membrane (ELM), ellipsoid (EZ) and interdigitation zone (IZ), subretinal fluid (SFR) height, and choroidal thickness (CT) were evaluated.
Patients were classified into responders and nonresponders based on SRF resorption.
Results.
Sixty-one eyes of 42 patients were included; 75.4% were classified as responders.
Final BCVA was significantly better in responders (p=0.002).
The baseline ONL was thicker (p<0.01) and intact ELM (67.2% vs.
16.4%), EZ (49.2% vs.
8.2%), and IZ (31.2% vs.
1.6%) were more prevalent in responders than in nonresponders.
Anatomic response was correlated with a thicker ONL (rs (59) = 0.416, p=0.001∗), intact ELM (rs (59) = 0.261, p=0.04∗), EZ (rs (59) = 0.278, p=0.03∗), and IZ (rs (59) = 0.318, p=0.01∗).
Binary logistic regression showed that a thicker ONL thickness increased the chance of an anatomic response to HD-PDT.
The other evaluated retinal layers did not have statistical significance in the binary regression model.
Conclusions.
cCSR responders to HD-PDT have a better final BCVA, a thicker baseline ONL, and an intact baseline ELM, EZ, and IZ.
However, ONL was the only predictor in a logistic regression model for SRF resorption.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sousa, Keissy& Viana, Ana Rita& Pires, Joana& Ferreira, Carla& Queirós, Lara& Falcão, Manuel. 2019. Outer Nuclear Layer as the Main Predictor to Anatomic Response to Half Dose Photodynamic Therapy in Chronic Central Serous Retinopathy. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1185841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sousa, Keissy…[et al.]. Outer Nuclear Layer as the Main Predictor to Anatomic Response to Half Dose Photodynamic Therapy in Chronic Central Serous Retinopathy. Journal of Ophthalmology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1185841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sousa, Keissy& Viana, Ana Rita& Pires, Joana& Ferreira, Carla& Queirós, Lara& Falcão, Manuel. Outer Nuclear Layer as the Main Predictor to Anatomic Response to Half Dose Photodynamic Therapy in Chronic Central Serous Retinopathy. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1185841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1185841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر